SPAG4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPAG4 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0031514Cellular componentmotile cilium
GO_0005737Cellular componentcytoplasm
GO_0005856Cellular componentcytoskeleton
GO_0005637Cellular componentnuclear inner membrane
GO_0005635Cellular componentnuclear envelope
GO_0005515Molecular functionprotein binding
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameSPAG4
Protein nameSperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4)
Sperm associated antigen 4
SynonymsSUN4
DescriptionFUNCTION: Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. .

AccessionsC9JJZ6
Q5JX49
ENST00000430878.1
Q9NPE6
ENST00000374273.8
ENST00000679710.1
ENST00000454819.1
A0A7P0Z4G5