SPACA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SPACA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPACA3 at tissue level.

III. Associated gene sets

GO_0050766Biological processpositive regulation of phagocytosis
GO_0042117Biological processmonocyte activation
GO_0035036Biological processsperm-egg recognition
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0043032Biological processpositive regulation of macrophage activation
GO_0002080Cellular componentacrosomal membrane
GO_0030141Cellular componentsecretory granule
GO_0001669Cellular componentacrosomal vesicle
GO_0036126Cellular componentsperm flagellum
GO_0005576Cellular componentextracellular region
GO_0043159Cellular componentacrosomal matrix
GO_0003796Molecular functionlysozyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPACA3
Protein nameSperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form]
Sperm acrosome membrane-associated protein 3
SynonymsLYZL3
LYZC
SPRASA
LYC3
UNQ424/PRO862
hCG_28136
SLLP1
DescriptionFUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. .

FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. .

FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. .

FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. .

AccessionsENST00000580599.5 [Q8IXA5-2]
A0A080YUZ7
ENST00000269053.8 [Q8IXA5-1]
Q05C28
ENST00000394638.1
E9PF91
Q8IXA5