SOCS5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0016567Biological processprotein ubiquitination
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0009968Biological processnegative regulation of signal transduction
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0071638Biological processnegative regulation of monocyte chemotactic protein-1 production
GO_0045629Biological processnegative regulation of T-helper 2 cell differentiation
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0035556Biological processintracellular signal transduction
GO_0050728Biological processnegative regulation of inflammatory response
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0097699Biological processvascular endothelial cell response to fluid shear stress
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0045627Biological processpositive regulation of T-helper 1 cell differentiation
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005829Cellular componentcytosol
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameSOCS5
Protein nameSuppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)
Suppressor of cytokine signaling 5
SynonymsCISH5
CIS6
CISH6
KIAA0671
DescriptionFUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. .

AccessionsO75159
A0A3B3ISP4
ENST00000394861.3
ENST00000650009.1
ENST00000306503.5