SMG7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0035303Biological processregulation of dephosphorylation
GO_0005829Cellular componentcytosol
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070034Molecular functiontelomerase RNA binding
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMG7
Protein nameBreast cancer-associated antigen SGA-56M (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), isoform CRA_a)
SMG7 nonsense mediated mRNA decay factor
Nonsense-mediated mRNA decay factor SMG7 (SMG-7 homolog) (hSMG-7)
Nonsense-mediated mRNA decay factor
SynonymshCG_39862
KIAA0250
C1orf16
SGA56M
EST1C
DescriptionFUNCTION: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. .

FUNCTION: Plays a role in nonsense-mediated mRNA decay. .

FUNCTION: Plays a role in nonsense-mediated mRNA decay. .

FUNCTION: Plays a role in nonsense-mediated mRNA decay. .

AccessionsENST00000347615.6 [Q92540-1]
Q92540
E9PEK3
E9PBK2
ENST00000688051.1
E9PD50
D6R9J3
ENST00000419169.5
ENST00000507469.5 [Q92540-4]
Q6TV06
ENST00000502375.1
ENST00000367537.7
ENST00000440812.7
A0A8I5KYV3
ENST00000685780.1
ENST00000515829.6 [Q92540-2]
ENST00000508461.5 [Q92540-5]
A0A8I5KSL3
ENST00000444547.6
B1ALB4