SLC7A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903826Biological processL-arginine transmembrane transport
GO_0015804Biological processneutral amino acid transport
GO_0031460Biological processglycine betaine transport
GO_1903401Biological processL-lysine transmembrane transport
GO_0015822Biological processornithine transport
GO_0006809Biological processnitric oxide biosynthetic process
GO_0003333Biological processamino acid transmembrane transport
GO_0015820Biological processL-leucine transport
GO_0005886Cellular componentplasma membrane
GO_0061459Molecular functionL-arginine transmembrane transporter activity
GO_0034618Molecular functionarginine binding
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0106439Molecular functionL-lysine:L-arginine antiporter activity
GO_0005515Molecular functionprotein binding
GO_0015174Molecular functionbasic amino acid transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC7A6
Protein nameY+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
Y+L amino acid transporter 2 (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2)
Solute carrier family 7 member 6
SynonymsKIAA0245
DescriptionFUNCTION: Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis . Also exchanges L-arginine with L-lysine in a sodium-independent manner . The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 . Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration (By similarity). May mediate transport of ornithine in retinal pigment epithelial (RPE) cells . May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte (By similarity). .

AccessionsENST00000219343.11
H3BRZ8
ENST00000566454.5
H3BPK5
ENST00000563146.1
ENST00000563080.1
ENST00000568088.5
H3BNF5
H3BUA4
J3QL60
ENST00000562727.1
Q92536
A0AUM0
ENST00000566579.5
H3BSB6
H3BPV6
ENST00000564708.1
H3BSV7
ENST00000648130.1
ENST00000566834.5
ENST00000618043.4
E7EPZ8
ENST00000379152.7
ENST00000568024.1
ENST00000567346.5
H3BUR2