SLC4A8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	14 studies	37% ± 11%	Explore
glutamatergic neuron	10 studies	45% ± 23%	Explore
GABAergic neuron	8 studies	46% ± 20%	Explore
neuron	7 studies	28% ± 14%	Explore
retina horizontal cell	6 studies	33% ± 9%	Explore
astrocyte	6 studies	30% ± 12%	Explore
amacrine cell	5 studies	25% ± 2%	Explore
interneuron	5 studies	50% ± 19%	Explore
retinal cone cell	5 studies	20% ± 2%	Explore
retinal bipolar neuron	4 studies	20% ± 4%	Explore
microglial cell	4 studies	23% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	23% ± 5%	Explore
GABAergic interneuron	3 studies	32% ± 5%	Explore
granule cell	3 studies	29% ± 11%	Explore
mast cell	3 studies	25% ± 11%	Explore
ciliated cell	3 studies	22% ± 4%	Explore
macrophage	3 studies	17% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	34% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4336.69	2618 / 2642	100%	11.02	704 / 705
adrenal gland	90%	1103.19	233 / 258	93%	14.22	214 / 230
ovary	90%	1640.72	162 / 180	54%	1.34	234 / 430
breast	39%	467.13	181 / 459	77%	6.40	857 / 1118
lung	51%	426.59	295 / 578	31%	0.92	362 / 1155
spleen	66%	413.37	159 / 241	0%	0	0 / 0
pancreas	15%	88.98	50 / 328	35%	1.26	62 / 178
lymph node	0%	0	0 / 0	45%	0.87	13 / 29
intestine	13%	80.37	123 / 966	29%	0.64	154 / 527
stomach	7%	44.58	25 / 359	29%	0.58	83 / 286
uterus	4%	42.46	6 / 170	22%	0.66	100 / 459
kidney	17%	165.74	15 / 89	4%	0.10	40 / 901
esophagus	1%	4.21	10 / 1445	20%	0.48	36 / 183
skin	8%	52.14	148 / 1809	10%	0.23	45 / 472
bladder	0%	0	0 / 21	13%	0.43	65 / 504
peripheral blood	12%	79.86	110 / 929	0%	0	0 / 0
prostate	9%	54.92	21 / 245	3%	0.04	13 / 502
tonsil	0%	0	0 / 0	7%	0.08	3 / 45
thymus	1%	6.78	7 / 653	3%	0.07	19 / 605
eye	0%	0	0 / 0	3%	0.12	2 / 80
adipose	2%	17.90	30 / 1204	0%	0	0 / 0
blood vessel	2%	12.20	23 / 1335	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.02	5 / 406
heart	0%	0.49	1 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042391	Biological process	regulation of membrane potential
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_2000302	Biological process	positive regulation of synaptic vesicle exocytosis
GO_0055085	Biological process	transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_1902476	Biological process	chloride transmembrane transport
GO_0110010	Biological process	basolateral protein secretion
GO_0051453	Biological process	regulation of intracellular pH
GO_0015701	Biological process	bicarbonate transport
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043195	Cellular component	terminal bouton
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0043679	Cellular component	axon terminus
GO_0032809	Cellular component	neuronal cell body membrane
GO_0043005	Cellular component	neuron projection
GO_0042734	Cellular component	presynaptic membrane
GO_0030425	Cellular component	dendrite
GO_0032279	Cellular component	asymmetric synapse
GO_0097457	Cellular component	hippocampal mossy fiber
GO_0008021	Cellular component	synaptic vesicle
GO_0032280	Cellular component	symmetric synapse
GO_0097386	Cellular component	glial cell projection
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015081	Molecular function	sodium ion transmembrane transporter activity
GO_0042802	Molecular function	identical protein binding
GO_0140892	Molecular function	sodium,bicarbonate:chloride antiporter activity
GO_0015106	Molecular function	bicarbonate transmembrane transporter activity
GO_0015108	Molecular function	chloride transmembrane transporter activity
GO_0005452	Molecular function	solute:inorganic anion antiporter activity
GO_0008510	Molecular function	sodium:bicarbonate symporter activity

IV. Literature review

[source]

Gene name	SLC4A8
Protein name	Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3)
Synonyms	KIAA0739 NBC3 NBC NDCBE1
Description	FUNCTION: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 . Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). .
Accessions	Q2Y0W8 ENST00000358657.7 [Q2Y0W8-5] ENST00000514353.7 [Q2Y0W8-7] ENST00000535225.6 [Q2Y0W8-8] ENST00000453097.7 [Q2Y0W8-1]

SLC4A8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review