SLC4A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042391Biological processregulation of membrane potential
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0006814Biological processsodium ion transport
GO_0015698Biological processinorganic anion transport
GO_0051453Biological processregulation of intracellular pH
GO_0015701Biological processbicarbonate transport
GO_0045821Biological processpositive regulation of glycolytic process
GO_0035725Biological processsodium ion transmembrane transport
GO_0036376Biological processsodium ion export across plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008509Molecular functionmonoatomic anion transmembrane transporter activity
GO_0015293Molecular functionsymporter activity
GO_0042802Molecular functionidentical protein binding
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0005515Molecular functionprotein binding
GO_0008510Molecular functionsodium:bicarbonate symporter activity

IV. Literature review

[source]
Gene nameSLC4A4
Protein nameSolute carrier family 4 member 4
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)
Anion exchange protein
SynonymsNBC
NBCE1
NBC1
DescriptionFUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. .

FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. .

FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. .

AccessionsENST00000340595.4 [Q9Y6R1-2]
Q9Y6R1
ENST00000649996.1 [Q9Y6R1-1]
A0A8V8TNB1
A0A1W2PRU6
A0A1W2PNW8
A5JJ20
ENST00000264485.11 [Q9Y6R1-1]
ENST00000639096.1
ENST00000638464.1
ENST00000698522.1
ENST00000425175.5 [Q9Y6R1-5]
ENST00000351898.10 [Q9Y6R1-4]
ENST00000512686.5 [Q9Y6R1-3]