SLC27A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905135Biological processbiotin import across plasma membrane
GO_0031652Biological processpositive regulation of heat generation
GO_0015909Biological processlong-chain fatty acid transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0033211Biological processadiponectin-activated signaling pathway
GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0006659Biological processphosphatidylserine biosynthetic process
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0015878Biological processbiotin transport
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0044381Biological processglucose import in response to insulin stimulus
GO_0140115Biological processexport across plasma membrane
GO_0015911Biological processlong-chain fatty acid import across plasma membrane
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0009409Biological processresponse to cold
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0001579Biological processmedium-chain fatty acid transport
GO_0032049Biological processcardiolipin biosynthetic process
GO_0006654Biological processphosphatidic acid biosynthetic process
GO_0071072Biological processnegative regulation of phospholipid biosynthetic process
GO_0006655Biological processphosphatidylglycerol biosynthetic process
GO_1990379Biological processlipid transport across blood-brain barrier
GO_0006646Biological processphosphatidylethanolamine biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0015245Molecular functionfatty acid transmembrane transporter activity
GO_0031957Molecular functionvery long-chain fatty acid-CoA ligase activity
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0015225Molecular functionbiotin transmembrane transporter activity
GO_0090434Molecular functionoleoyl-CoA ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0000166Molecular functionnucleotide binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0005515Molecular functionprotein binding
GO_1901480Molecular functionoleate transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC27A1
Protein nameLong-chain fatty acid transport protein 1 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 1) (FATP-1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 1) (Very long-chain acyl-CoA synthetase) (EC 6.2.1.-)
Long-chain-fatty-acid--CoA ligase
Solute carrier family 27 member 1
SynonymsACSVL5
FATP1
DescriptionFUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane . Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier . .

AccessionsQ6PCB7
ENST00000599380.5
ENST00000600277.5
Q96DY3
B7Z225
M0QZC9
M0QXY2
ENST00000599965.1
ENST00000598424.5 [Q6PCB7-2]
ENST00000252595.12 [Q6PCB7-1]
ENST00000600297.1