SIGLEC10 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIGLEC10 at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_0007155Biological processcell adhesion
GO_0045087Biological processinnate immune response
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0042169Molecular functionSH2 domain binding
GO_0019902Molecular functionphosphatase binding
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding
GO_0033691Molecular functionsialic acid binding

IV. Literature review

[source]
Gene nameSIGLEC10
Protein nameSialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)
SIGLEC10 protein
Sialic acid binding Ig like lectin 10
SynonymsSLG2
UNQ477/PRO940
DescriptionFUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules . Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells . Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity). .

AccessionsENST00000353836.9 [Q96LC7-2]
ENST00000339313.10 [Q96LC7-1]
E9PJA1
ENST00000442846.7 [Q96LC7-8]
E9PL79
ENST00000436984.6 [Q96LC7-7]
ENST00000439889.6 [Q96LC7-3]
B7ZL04
B7ZL06
Q96LC7
ENST00000530476.1
ENST00000529627.1
ENST00000525998.5
ENST00000441969.7 [Q96LC7-6]
E9PKV9