I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 25% ± 7% | |
| GABAergic neuron | 3 studies | 22% ± 1% | |
| astrocyte | 3 studies | 28% ± 3% | |
| glutamatergic neuron | 3 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 8 studies | 25% ± 7% | |
| GABAergic neuron | 3 studies | 22% ± 1% | |
| astrocyte | 3 studies | 28% ± 3% | |
| glutamatergic neuron | 3 studies | 28% ± 5% |
Insufficient scRNA-seq data for expression of SHROOM2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 98% | 1184.75 | 239 / 245 | 100% | 17.54 | 502 / 502 |
| brain | 99% | 1031.21 | 2622 / 2642 | 98% | 12.02 | 688 / 705 |
| thymus | 99% | 385.90 | 648 / 653 | 93% | 5.78 | 562 / 605 |
| pancreas | 99% | 491.98 | 326 / 328 | 93% | 6.82 | 165 / 178 |
| ovary | 100% | 1644.24 | 180 / 180 | 89% | 7.45 | 381 / 430 |
| kidney | 100% | 876.37 | 89 / 89 | 89% | 6.64 | 798 / 901 |
| uterus | 95% | 369.33 | 162 / 170 | 92% | 10.22 | 420 / 459 |
| lung | 100% | 1206.84 | 578 / 578 | 85% | 9.16 | 986 / 1155 |
| breast | 85% | 322.56 | 389 / 459 | 93% | 10.15 | 1036 / 1118 |
| adrenal gland | 99% | 468.69 | 256 / 258 | 76% | 4.16 | 174 / 230 |
| skin | 77% | 615.49 | 1398 / 1809 | 91% | 14.90 | 431 / 472 |
| liver | 100% | 541.36 | 225 / 226 | 67% | 3.67 | 274 / 406 |
| intestine | 81% | 271.56 | 786 / 966 | 72% | 5.41 | 381 / 527 |
| bladder | 62% | 469.10 | 13 / 21 | 87% | 9.40 | 438 / 504 |
| stomach | 78% | 291.81 | 280 / 359 | 67% | 5.68 | 193 / 286 |
| esophagus | 56% | 469.56 | 814 / 1445 | 81% | 10.46 | 149 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 10.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.94 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 95% | 4.80 | 76 / 80 |
| adipose | 75% | 196.13 | 908 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 52% | 106.32 | 126 / 241 | 0% | 0 | 0 / 0 |
| heart | 35% | 75.99 | 301 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 17% | 35.06 | 224 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.19 | 1 / 29 |
| peripheral blood | 2% | 10.20 | 23 / 929 | 0% | 0 | 0 / 0 |
| muscle | 1% | 1.88 | 9 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008057 | Biological process | eye pigment granule organization |
| GO_0048593 | Biological process | camera-type eye morphogenesis |
| GO_0045176 | Biological process | apical protein localization |
| GO_0032438 | Biological process | melanosome organization |
| GO_0032401 | Biological process | establishment of melanosome localization |
| GO_0043482 | Biological process | cellular pigment accumulation |
| GO_0051017 | Biological process | actin filament bundle assembly |
| GO_0007015 | Biological process | actin filament organization |
| GO_0007420 | Biological process | brain development |
| GO_0043010 | Biological process | camera-type eye development |
| GO_0002089 | Biological process | lens morphogenesis in camera-type eye |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0043583 | Biological process | ear development |
| GO_0016477 | Biological process | cell migration |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005874 | Cellular component | microtubule |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030864 | Cellular component | cortical actin cytoskeleton |
| GO_0043296 | Cellular component | apical junction complex |
| GO_0005912 | Cellular component | adherens junction |
| GO_0005923 | Cellular component | bicellular tight junction |
| GO_0015280 | Molecular function | ligand-gated sodium channel activity |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SHROOM2 |
| Protein name | Protein Shroom2 (Apical-like protein) (Protein APXL) Shroom family member 2 |
| Synonyms | APXL |
| Description | FUNCTION: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution (By similarity). . |
| Accessions | ENST00000418909.6 F5H3B6 Q13796 C9IZC6 ENST00000380913.8 ENST00000452575.1 |
