I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| interneuron | 5 studies | 38% ± 22% | |
| GABAergic neuron | 4 studies | 50% ± 18% | |
| glutamatergic neuron | 4 studies | 53% ± 21% | |
| neuron | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| interneuron | 5 studies | 38% ± 22% | |
| GABAergic neuron | 4 studies | 50% ± 18% | |
| glutamatergic neuron | 4 studies | 53% ± 21% | |
| neuron | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 44% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 96% | 5389.19 | 2525 / 2642 | 94% | 17.26 | 661 / 705 |
| adrenal gland | 59% | 277.94 | 151 / 258 | 79% | 9.92 | 182 / 230 |
| ovary | 10% | 34.03 | 18 / 180 | 72% | 8.09 | 310 / 430 |
| skin | 14% | 44.79 | 257 / 1809 | 29% | 1.55 | 137 / 472 |
| uterus | 19% | 103.05 | 32 / 170 | 9% | 0.51 | 43 / 459 |
| breast | 2% | 7.89 | 8 / 459 | 13% | 0.27 | 146 / 1118 |
| pancreas | 0% | 0 | 0 / 328 | 12% | 0.39 | 22 / 178 |
| kidney | 0% | 0 | 0 / 89 | 10% | 0.29 | 88 / 901 |
| esophagus | 0% | 0.42 | 2 / 1445 | 9% | 0.17 | 16 / 183 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.35 | 6 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.44 | 2 / 29 |
| thymus | 0% | 1.29 | 3 / 653 | 5% | 0.15 | 32 / 605 |
| prostate | 2% | 7.61 | 6 / 245 | 2% | 0.06 | 12 / 502 |
| lung | 0% | 0 | 0 / 578 | 5% | 0.13 | 55 / 1155 |
| intestine | 1% | 1.58 | 5 / 966 | 3% | 0.12 | 18 / 527 |
| stomach | 0% | 0 | 0 / 359 | 3% | 0.06 | 8 / 286 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.06 | 12 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.06 | 3 / 406 |
| muscle | 1% | 2.55 | 5 / 803 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.66 | 3 / 1204 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.78 | 2 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 1.90 | 1 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050894 | Biological process | determination of affect |
| GO_0046959 | Biological process | habituation |
| GO_0060997 | Biological process | dendritic spine morphogenesis |
| GO_0007616 | Biological process | long-term memory |
| GO_0099562 | Biological process | maintenance of postsynaptic density structure |
| GO_0050885 | Biological process | neuromuscular process controlling balance |
| GO_0008306 | Biological process | associative learning |
| GO_0060013 | Biological process | righting reflex |
| GO_2000463 | Biological process | positive regulation of excitatory postsynaptic potential |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0071625 | Biological process | vocalization behavior |
| GO_0042048 | Biological process | olfactory behavior |
| GO_0060999 | Biological process | positive regulation of dendritic spine development |
| GO_2000311 | Biological process | regulation of AMPA receptor activity |
| GO_0060074 | Biological process | synapse maturation |
| GO_0030534 | Biological process | adult behavior |
| GO_0035418 | Biological process | protein localization to synapse |
| GO_0035176 | Biological process | social behavior |
| GO_0032232 | Biological process | negative regulation of actin filament bundle assembly |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0016020 | Cellular component | membrane |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030425 | Cellular component | dendrite |
| GO_0005829 | Cellular component | cytosol |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0060076 | Cellular component | excitatory synapse |
| GO_0098919 | Molecular function | structural constituent of postsynaptic density |
| GO_0030160 | Molecular function | synaptic receptor adaptor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0031877 | Molecular function | somatostatin receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0071532 | Molecular function | ankyrin repeat binding |
| GO_0035255 | Molecular function | ionotropic glutamate receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0017124 | Molecular function | SH3 domain binding |
| Gene name | SHANK1 |
| Protein name | SH3 and multiple ankyrin repeat domains 1 SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) |
| Synonyms | |
| Description | FUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Accessions | ENST00000293441.6 [Q9Y566-1] ENST00000468654.2 Q9Y566 M0QYB5 ENST00000359082.3 [Q9Y566-3] H9KV90 ENST00000391814.5 |
