Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 25 studies | 26% ± 9% | |
endothelial cell | 13 studies | 32% ± 14% | |
smooth muscle cell | 13 studies | 22% ± 6% | |
oligodendrocyte | 12 studies | 35% ± 12% | |
pericyte | 11 studies | 23% ± 6% | |
glutamatergic neuron | 10 studies | 40% ± 25% | |
macrophage | 9 studies | 31% ± 11% | |
myofibroblast cell | 8 studies | 29% ± 8% | |
basal cell | 8 studies | 32% ± 22% | |
GABAergic neuron | 8 studies | 49% ± 24% | |
neuron | 7 studies | 35% ± 19% | |
connective tissue cell | 7 studies | 29% ± 11% | |
retinal ganglion cell | 6 studies | 38% ± 13% | |
epithelial cell | 6 studies | 31% ± 21% | |
type II pneumocyte | 6 studies | 27% ± 10% | |
interneuron | 5 studies | 51% ± 22% | |
retina horizontal cell | 5 studies | 34% ± 13% | |
goblet cell | 5 studies | 45% ± 21% | |
glial cell | 4 studies | 24% ± 6% | |
granule cell | 4 studies | 23% ± 4% | |
club cell | 4 studies | 21% ± 5% | |
cardiac muscle cell | 4 studies | 22% ± 3% | |
myeloid cell | 4 studies | 23% ± 3% | |
endothelial cell of lymphatic vessel | 4 studies | 25% ± 9% | |
Schwann cell | 4 studies | 39% ± 16% | |
squamous epithelial cell | 3 studies | 51% ± 22% | |
abnormal cell | 3 studies | 33% ± 22% | |
GABAergic interneuron | 3 studies | 40% ± 5% | |
microglial cell | 3 studies | 36% ± 10% | |
rod bipolar cell | 3 studies | 21% ± 5% | |
respiratory goblet cell | 3 studies | 29% ± 10% | |
secretory cell | 3 studies | 16% ± 1% | |
hepatocyte | 3 studies | 61% ± 21% | |
mucus secreting cell | 3 studies | 29% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 12264.36 | 1445 / 1445 | 99% | 47.24 | 182 / 183 |
lung | 100% | 9842.01 | 577 / 578 | 99% | 40.96 | 1144 / 1155 |
breast | 100% | 8733.91 | 459 / 459 | 98% | 36.28 | 1099 / 1118 |
intestine | 100% | 12445.79 | 966 / 966 | 98% | 28.82 | 518 / 527 |
uterus | 100% | 21690.98 | 170 / 170 | 98% | 36.11 | 450 / 459 |
skin | 100% | 13929.68 | 1808 / 1809 | 97% | 34.30 | 457 / 472 |
bladder | 100% | 12248.05 | 21 / 21 | 95% | 26.49 | 481 / 504 |
stomach | 96% | 6120.57 | 345 / 359 | 98% | 29.36 | 281 / 286 |
thymus | 99% | 5664.81 | 646 / 653 | 88% | 15.54 | 535 / 605 |
prostate | 100% | 11151.13 | 245 / 245 | 86% | 14.92 | 430 / 502 |
ovary | 100% | 16072.48 | 180 / 180 | 85% | 17.96 | 366 / 430 |
brain | 99% | 8458.34 | 2627 / 2642 | 86% | 15.24 | 604 / 705 |
pancreas | 75% | 2373.43 | 246 / 328 | 99% | 48.67 | 176 / 178 |
adrenal gland | 99% | 4529.83 | 255 / 258 | 74% | 17.39 | 171 / 230 |
kidney | 75% | 2726.73 | 67 / 89 | 76% | 15.57 | 688 / 901 |
liver | 88% | 6258.58 | 200 / 226 | 61% | 8.35 | 249 / 406 |
adipose | 100% | 9902.73 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 11370.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 36.45 | 80 / 80 |
spleen | 100% | 7567.84 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 46.11 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.90 | 1 / 1 |
muscle | 98% | 6074.45 | 787 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 5671.65 | 836 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 8.23 | 17 / 29 |
peripheral blood | 18% | 944.43 | 170 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006801 | Biological process | superoxide metabolic process |
GO_0001701 | Biological process | in utero embryonic development |
GO_0072675 | Biological process | osteoclast fusion |
GO_0042554 | Biological process | superoxide anion generation |
GO_0042995 | Cellular component | cell projection |
GO_0002102 | Cellular component | podosome |
GO_0005829 | Cellular component | cytosol |
GO_0070161 | Cellular component | anchoring junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0002020 | Molecular function | protease binding |
GO_0016176 | Molecular function | superoxide-generating NADPH oxidase activator activity |
GO_0070273 | Molecular function | phosphatidylinositol-4-phosphate binding |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0005515 | Molecular function | protein binding |
GO_0010314 | Molecular function | phosphatidylinositol-5-phosphate binding |
GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
Gene name | SH3PXD2A |
Protein name | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) SH3 and PX domains 2A |
Synonyms | TKS5 SH3MD1 KIAA0418 FISH |
Description | FUNCTION: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. . |
Accessions | ENST00000355946.7 [Q5TCZ1-3] ENST00000687380.1 ENST00000369774.9 [Q5TCZ1-1] A0A8I5KQW5 Q5TCZ1 |