SH3PXD2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006801Biological processsuperoxide metabolic process
GO_0001701Biological processin utero embryonic development
GO_0072675Biological processosteoclast fusion
GO_0042554Biological processsuperoxide anion generation
GO_0042995Cellular componentcell projection
GO_0002102Cellular componentpodosome
GO_0005829Cellular componentcytosol
GO_0070161Cellular componentanchoring junction
GO_0005737Cellular componentcytoplasm
GO_0002020Molecular functionprotease binding
GO_0016176Molecular functionsuperoxide-generating NADPH oxidase activator activity
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameSH3PXD2A
Protein nameSH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
SH3 and PX domains 2A
SynonymsTKS5
SH3MD1
KIAA0418
FISH
DescriptionFUNCTION: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. .

AccessionsENST00000355946.7 [Q5TCZ1-3]
ENST00000687380.1
ENST00000369774.9 [Q5TCZ1-1]
A0A8I5KQW5
Q5TCZ1