SH2B2 | OmnibusX

Name	Number of supported studies	Average coverage
B cell	4 studies	22% ± 6%	Explore
non-classical monocyte	3 studies	24% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SH2B2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	99%	493.13	647 / 653	96%	9.74	579 / 605
brain	94%	450.84	2492 / 2642	99%	22.29	699 / 705
bladder	100%	400.10	21 / 21	93%	10.86	470 / 504
uterus	99%	497.11	169 / 170	93%	11.12	428 / 459
lung	99%	588.81	572 / 578	93%	8.56	1076 / 1155
kidney	99%	525.00	88 / 89	88%	8.21	791 / 901
prostate	98%	467.96	239 / 245	87%	5.10	439 / 502
breast	97%	367.11	447 / 459	87%	7.28	971 / 1118
intestine	88%	310.52	847 / 966	92%	9.20	483 / 527
esophagus	77%	216.36	1116 / 1445	95%	10.75	174 / 183
ovary	71%	158.81	128 / 180	100%	24.83	430 / 430
skin	74%	235.79	1336 / 1809	92%	9.72	433 / 472
stomach	67%	167.88	240 / 359	94%	10.39	268 / 286
adrenal gland	72%	149.14	186 / 258	79%	8.05	182 / 230
pancreas	30%	58.88	100 / 328	93%	8.37	166 / 178
lymph node	0%	0	0 / 0	100%	101.46	29 / 29
muscle	100%	1935.60	803 / 803	0%	0	0 / 0
spleen	100%	1456.52	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.40	1 / 1
peripheral blood	100%	2395.78	927 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	8.43	43 / 45
adipose	95%	420.77	1141 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	93%	7.27	74 / 80
blood vessel	81%	235.33	1088 / 1335	0%	0	0 / 0
liver	23%	39.74	51 / 226	45%	3.13	181 / 406
heart	36%	87.88	312 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0050851	Biological process	antigen receptor-mediated signaling pathway
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0050873	Biological process	brown fat cell differentiation
GO_0001922	Biological process	B-1 B cell homeostasis
GO_0046578	Biological process	regulation of Ras protein signal transduction
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0030036	Biological process	actin cytoskeleton organization
GO_0035556	Biological process	intracellular signal transduction
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0007399	Biological process	nervous system development
GO_0019222	Biological process	regulation of metabolic process
GO_0001726	Cellular component	ruffle
GO_0005886	Cellular component	plasma membrane
GO_0005884	Cellular component	actin filament
GO_0001725	Cellular component	stress fiber
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0042802	Molecular function	identical protein binding
GO_0005068	Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity
GO_0042169	Molecular function	SH2 domain binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding

Gene name	SH2B2
Protein name	SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) SH2B adapter protein 2 SH2B adaptor protein 2
Synonyms	APS
Description	FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. .
Accessions	ENST00000536178.3 [O14492-1] A0A087X016 C9JK89 ENST00000444095 ENST00000617975.2 O14492 ENST00000444095.3 [O14492-1]

SH2B2 report