SGPP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061469Biological processregulation of type B pancreatic cell proliferation
GO_0006670Biological processsphingosine metabolic process
GO_0030149Biological processsphingolipid catabolic process
GO_0046839Biological processphospholipid dephosphorylation
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070780Molecular functiondihydrosphingosine-1-phosphate phosphatase activity
GO_0042392Molecular functionsphingosine-1-phosphate phosphatase activity

IV. Literature review

[source]
Gene nameSGPP2
Protein nameSGPP2 protein
Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2)
Uncharacterized protein SGPP2
Synonyms
DescriptionFUNCTION: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro . Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling . Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). .

AccessionsQ53QF5
Q3B870
Q4ZFX2
Q8IWX5
ENST00000321276.8 [Q8IWX5-1]