Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 8 studies | 31% ± 15% | |
endothelial cell | 7 studies | 27% ± 9% | |
astrocyte | 6 studies | 27% ± 8% | |
epithelial cell | 5 studies | 37% ± 12% | |
ciliated cell | 5 studies | 25% ± 7% | |
GABAergic neuron | 5 studies | 33% ± 11% | |
microglial cell | 4 studies | 19% ± 2% | |
myeloid cell | 4 studies | 21% ± 3% | |
basal cell | 4 studies | 27% ± 10% | |
glutamatergic neuron | 4 studies | 48% ± 15% | |
squamous epithelial cell | 3 studies | 34% ± 23% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 5% | |
monocyte | 3 studies | 16% ± 1% | |
club cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 18% ± 2% | |
fibroblast | 3 studies | 17% ± 1% | |
interneuron | 3 studies | 37% ± 15% | |
neuron | 3 studies | 26% ± 2% | |
oligodendrocyte | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 4560.29 | 21 / 21 | 100% | 71.35 | 504 / 504 |
esophagus | 100% | 3965.92 | 1445 / 1445 | 100% | 48.74 | 183 / 183 |
ovary | 100% | 2510.40 | 180 / 180 | 100% | 67.18 | 430 / 430 |
stomach | 100% | 2010.72 | 359 / 359 | 100% | 40.28 | 286 / 286 |
lung | 100% | 2720.81 | 577 / 578 | 100% | 53.38 | 1155 / 1155 |
prostate | 100% | 3892.79 | 245 / 245 | 100% | 57.31 | 501 / 502 |
brain | 100% | 2437.96 | 2639 / 2642 | 100% | 41.04 | 704 / 705 |
breast | 100% | 2781.95 | 459 / 459 | 100% | 63.50 | 1115 / 1118 |
intestine | 100% | 3513.28 | 966 / 966 | 100% | 38.66 | 525 / 527 |
thymus | 100% | 4483.97 | 653 / 653 | 99% | 52.71 | 600 / 605 |
pancreas | 100% | 3009.82 | 327 / 328 | 99% | 52.01 | 177 / 178 |
uterus | 100% | 3708.94 | 170 / 170 | 99% | 49.92 | 453 / 459 |
kidney | 100% | 3305.90 | 89 / 89 | 99% | 36.67 | 889 / 901 |
liver | 100% | 3291.32 | 226 / 226 | 96% | 27.63 | 389 / 406 |
skin | 100% | 6481.51 | 1809 / 1809 | 95% | 24.97 | 448 / 472 |
adrenal gland | 100% | 2708.67 | 258 / 258 | 93% | 48.45 | 213 / 230 |
adipose | 100% | 2574.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 32.96 | 29 / 29 |
spleen | 100% | 4169.00 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 52.09 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 74.49 | 1 / 1 |
blood vessel | 99% | 1857.05 | 1327 / 1335 | 0% | 0 | 0 / 0 |
heart | 90% | 1071.73 | 776 / 861 | 0% | 0 | 0 / 0 |
muscle | 86% | 1067.61 | 694 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 84% | 1249.83 | 781 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 81% | 13.23 | 65 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0007283 | Biological process | spermatogenesis |
GO_0030097 | Biological process | hemopoiesis |
GO_0008209 | Biological process | androgen metabolic process |
GO_0009791 | Biological process | post-embryonic development |
GO_0001553 | Biological process | luteinization |
GO_0010761 | Biological process | fibroblast migration |
GO_0006672 | Biological process | ceramide metabolic process |
GO_0001570 | Biological process | vasculogenesis |
GO_0001822 | Biological process | kidney development |
GO_0040014 | Biological process | regulation of multicellular organism growth |
GO_0006631 | Biological process | fatty acid metabolic process |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0060021 | Biological process | roof of mouth development |
GO_0030149 | Biological process | sphingolipid catabolic process |
GO_0008210 | Biological process | estrogen metabolic process |
GO_0033327 | Biological process | Leydig cell differentiation |
GO_0060325 | Biological process | face morphogenesis |
GO_0048705 | Biological process | skeletal system morphogenesis |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0008117 | Molecular function | sphinganine-1-phosphate aldolase activity |
GO_0030170 | Molecular function | pyridoxal phosphate binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SGPL1 |
Protein name | Sphingosine-1-phosphate lyase 1 sphinganine-1-phosphate aldolase (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) |
Synonyms | KIAA1252 |
Description | FUNCTION: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis . Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). . |
Accessions | A0A8V8TLU3 A0A8V8TN38 A0A8V8TLB6 ENST00000697928.1 ENST00000697988.1 ENST00000697989.1 ENST00000697932.1 ENST00000697931.1 A0A8V8TLU8 ENST00000697926.1 H7BXL7 A0A8V8TN35 ENST00000373202.8 O95470 ENST00000697925.1 ENST00000299297.8 ENST00000697927.1 ENST00000697929.1 ENST00000697930.1 |