SGPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0007283Biological processspermatogenesis
GO_0030097Biological processhemopoiesis
GO_0008209Biological processandrogen metabolic process
GO_0009791Biological processpost-embryonic development
GO_0001553Biological processluteinization
GO_0010761Biological processfibroblast migration
GO_0006672Biological processceramide metabolic process
GO_0001570Biological processvasculogenesis
GO_0001822Biological processkidney development
GO_0040014Biological processregulation of multicellular organism growth
GO_0006631Biological processfatty acid metabolic process
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0060021Biological processroof of mouth development
GO_0030149Biological processsphingolipid catabolic process
GO_0008210Biological processestrogen metabolic process
GO_0033327Biological processLeydig cell differentiation
GO_0060325Biological processface morphogenesis
GO_0048705Biological processskeletal system morphogenesis
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0008117Molecular functionsphinganine-1-phosphate aldolase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSGPL1
Protein nameSphingosine-1-phosphate lyase 1
sphinganine-1-phosphate aldolase (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
SynonymsKIAA1252
DescriptionFUNCTION: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis . Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). .

AccessionsA0A8V8TLU3
A0A8V8TN38
A0A8V8TLB6
ENST00000697928.1
ENST00000697988.1
ENST00000697989.1
ENST00000697932.1
ENST00000697931.1
A0A8V8TLU8
ENST00000697926.1
H7BXL7
A0A8V8TN35
ENST00000373202.8
O95470
ENST00000697925.1
ENST00000299297.8
ENST00000697927.1
ENST00000697929.1
ENST00000697930.1