SGK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	11 studies	48% ± 17%	Explore
astrocyte	11 studies	41% ± 19%	Explore
macrophage	8 studies	31% ± 13%	Explore
oligodendrocyte precursor cell	8 studies	34% ± 14%	Explore
endothelial cell	8 studies	23% ± 2%	Explore
myeloid cell	7 studies	32% ± 15%	Explore
microglial cell	7 studies	36% ± 6%	Explore
adipocyte	6 studies	27% ± 8%	Explore
classical monocyte	5 studies	22% ± 6%	Explore
GABAergic neuron	5 studies	25% ± 3%	Explore
epithelial cell	5 studies	31% ± 15%	Explore
dendritic cell	5 studies	29% ± 7%	Explore
endothelial cell of lymphatic vessel	4 studies	24% ± 5%	Explore
glutamatergic neuron	4 studies	36% ± 10%	Explore
interneuron	4 studies	36% ± 17%	Explore
retinal pigment epithelial cell	3 studies	57% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	39% ± 14%	Explore
lung	3 studies	25% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1370.59	653 / 653	98%	14.94	593 / 605
breast	100%	2486.61	459 / 459	98%	18.23	1093 / 1118
lung	100%	1142.23	577 / 578	96%	5.08	1113 / 1155
brain	99%	1632.78	2610 / 2642	97%	6.00	685 / 705
prostate	100%	1104.16	245 / 245	96%	5.96	481 / 502
kidney	100%	1029.96	89 / 89	95%	5.17	855 / 901
pancreas	100%	1161.73	328 / 328	94%	4.20	167 / 178
esophagus	100%	645.95	1445 / 1445	93%	5.29	171 / 183
skin	100%	1216.74	1808 / 1809	92%	13.21	434 / 472
stomach	100%	721.34	359 / 359	91%	4.36	260 / 286
liver	100%	898.87	226 / 226	90%	5.00	367 / 406
uterus	100%	1012.18	170 / 170	90%	4.13	411 / 459
intestine	100%	893.49	966 / 966	89%	4.16	469 / 527
adrenal gland	100%	764.16	258 / 258	83%	3.19	192 / 230
ovary	100%	971.92	180 / 180	82%	3.08	352 / 430
bladder	100%	631.00	21 / 21	81%	3.32	410 / 504
spleen	100%	915.92	241 / 241	0%	0	0 / 0
adipose	100%	974.21	1203 / 1204	0%	0	0 / 0
blood vessel	100%	965.84	1333 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	4.89	42 / 45
heart	92%	428.19	794 / 861	0%	0	0 / 0
muscle	91%	320.33	732 / 803	0%	0	0 / 0
peripheral blood	82%	399.70	765 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	76%	3.15	22 / 29
eye	0%	0	0 / 0	66%	4.48	53 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0001558	Biological process	regulation of cell growth
GO_0035556	Biological process	intracellular signal transduction
GO_0030334	Biological process	regulation of cell migration
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0051090	Biological process	regulation of DNA-binding transcription factor activity
GO_0006468	Biological process	protein phosphorylation
GO_0042127	Biological process	regulation of cell population proliferation
GO_0055037	Cellular component	recycling endosome
GO_0005769	Cellular component	early endosome
GO_0005829	Cellular component	cytosol
GO_0106310	Molecular function	protein serine kinase activity
GO_0005246	Molecular function	calcium channel regulator activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0004672	Molecular function	protein kinase activity
GO_0017081	Molecular function	chloride channel regulator activity
GO_0015459	Molecular function	potassium channel regulator activity
GO_0005524	Molecular function	ATP binding
GO_0017080	Molecular function	sodium channel regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SGK3
Protein name	Serum/glucocorticoid regulated kinase family member 3 Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
Synonyms	SGKL CISK
Description	FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. .
Accessions	ENST00000345714.8 [Q96BR1-1] E5RK28 E5RJV7 ENST00000521960.5 ENST00000522629.5 E5RHY6 E5RHX2 ENST00000518388.5 E5RHR8 ENST00000520976.5 [Q96BR1-2] ENST00000519396.5 ENST00000396596.2 [Q96BR1-1] ENST00000522398.5 [Q96BR1-1] ENST00000521198.7 [Q96BR1-1] ENST00000521152.5 Q96BR1

SGK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review