SFTPA1 | OmnibusX

Name	Number of supported studies	Average coverage
type II pneumocyte	11 studies	85% ± 17%	Explore
type I pneumocyte	8 studies	32% ± 23%	Explore
club cell	5 studies	43% ± 29%	Explore
T cell	3 studies	50% ± 32%	Explore
endothelial cell of lymphatic vessel	3 studies	45% ± 36%	Explore
fibroblast	3 studies	43% ± 36%	Explore
ciliated cell	3 studies	44% ± 34%	Explore

Name	Number of supported studies	Average coverage
lung	7 studies	33% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	219784.55	577 / 578	65%	1970.10	745 / 1155
thymus	69%	50.08	451 / 653	10%	73.34	60 / 605
pancreas	74%	32.98	244 / 328	0%	0	0 / 178
heart	56%	44.81	478 / 861	0%	0	0 / 0
prostate	55%	22.55	134 / 245	0%	0	0 / 502
esophagus	52%	23.81	751 / 1445	1%	8.77	1 / 183
adrenal gland	52%	38.06	133 / 258	0%	0	0 / 230
intestine	51%	28.32	495 / 966	0%	0.45	1 / 527
peripheral blood	50%	62.33	461 / 929	0%	0	0 / 0
adipose	50%	37.87	597 / 1204	0%	0	0 / 0
muscle	50%	38.06	398 / 803	0%	0	0 / 0
stomach	49%	19.48	177 / 359	0%	0	0 / 286
brain	48%	27.50	1277 / 2642	0%	0	0 / 705
breast	48%	22.21	220 / 459	0%	0	0 / 1118
blood vessel	46%	47.43	612 / 1335	0%	0	0 / 0
ovary	46%	388.79	82 / 180	0%	0	0 / 430
liver	45%	39.71	102 / 226	0%	0	0 / 406
spleen	45%	16.80	108 / 241	0%	0	0 / 0
skin	44%	49.69	787 / 1809	1%	8.31	6 / 472
kidney	44%	17.65	39 / 89	0%	0	0 / 901
uterus	42%	15.51	72 / 170	0%	0	0 / 459
bladder	5%	0.95	1 / 21	6%	175.92	30 / 504
tonsil	0%	0	0 / 0	2%	1.95	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0008228	Biological process	opsonization
GO_0006869	Biological process	lipid transport
GO_0007585	Biological process	respiratory gaseous exchange by respiratory system
GO_0045334	Cellular component	clathrin-coated endocytic vesicle
GO_0005615	Cellular component	extracellular space
GO_0005581	Cellular component	collagen trimer
GO_0005576	Cellular component	extracellular region
GO_0042599	Cellular component	lamellar body
GO_0005771	Cellular component	multivesicular body
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005319	Molecular function	lipid transporter activity
GO_0030246	Molecular function	carbohydrate binding
GO_0005515	Molecular function	protein binding

Gene name	SFTPA1
Protein name	Surfactant protein A1 Surfactant protein A1 variant AB'D' 6A (Surfactant protein A1 variant ACD' 6A) Pulmonary surfactant-associated protein A1 (PSP-A) (PSPA) (SP-A) (SP-A1) (35 kDa pulmonary surfactant-associated protein) (Alveolar proteinosis protein) (Collectin-4)
Synonyms	SFTP1 SFTPA1B COLEC4 SFTPA PSAP
Description	FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). .; FUNCTION: (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule . Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages . .; FUNCTION: (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen . When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen . .
Accessions	ENST00000429958.5 ENST00000428376.6 [Q8IWL2-1] A0A0C4DG36 K4N2H0 ENST00000419470.6 [Q8IWL2-2] ENST00000398636.8 [Q8IWL2-1] Q8IWL2

SFTPA1 report