SESTD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904878Biological processnegative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0034704Cellular componentcalcium channel complex
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0070300Molecular functionphosphatidic acid binding
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0031210Molecular functionphosphatidylcholine binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameSESTD1
Protein nameSEC14 and spectrin domain containing 1
SEC14 domain and spectrin repeat-containing protein 1 (Huntingtin-interacting protein-like protein) (Protein Solo)
Alternative protein SESTD1
SESTD1 protein
SynonymsSOLO
DescriptionFUNCTION: May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. .

AccessionsQ86VW0
ENST00000428443.8
ENST00000446758.5
ENST00000435047.5
L8EBH0
Q7Z6D3
ENST00000335289.5
H7BXT9
C9J4X8
ENST00000440010.5
H0Y774
C9JHW6