SESN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SESN2 at tissue level.

III. Associated gene sets

GO_0070328Biological processtriglyceride homeostasis
GO_0042149Biological processcellular response to glucose starvation
GO_0098869Biological processcellular oxidant detoxification
GO_1990253Biological processcellular response to leucine starvation
GO_0042593Biological processglucose homeostasis
GO_0009749Biological processresponse to glucose
GO_1903432Biological processregulation of TORC1 signaling
GO_1901031Biological processregulation of response to reactive oxygen species
GO_0032868Biological processresponse to insulin
GO_0001932Biological processregulation of protein phosphorylation
GO_0032042Biological processmitochondrial DNA metabolic process
GO_1904504Biological processpositive regulation of lipophagy
GO_1902010Biological processnegative regulation of translation in response to endoplasmic reticulum stress
GO_0006111Biological processregulation of gluconeogenesis
GO_0072593Biological processreactive oxygen species metabolic process
GO_0071233Biological processcellular response to L-leucine
GO_0034599Biological processcellular response to oxidative stress
GO_0016239Biological processpositive regulation of macroautophagy
GO_0034198Biological processcellular response to amino acid starvation
GO_0071230Biological processcellular response to amino acid stimulus
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006635Biological processfatty acid beta-oxidation
GO_0046323Biological processglucose import
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0030308Biological processnegative regulation of cell growth
GO_0005739Cellular componentmitochondrion
GO_0031588Cellular componentnucleotide-activated protein kinase complex
GO_0031932Cellular componentTORC2 complex
GO_0005829Cellular componentcytosol
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0005737Cellular componentcytoplasm
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0004601Molecular functionperoxidase activity
GO_0005092Molecular functionGDP-dissociation inhibitor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042731Molecular functionPH domain binding
GO_0032542Molecular functionsulfiredoxin activity
GO_0070728Molecular functionL-leucine binding
GO_0016684Molecular functionoxidoreductase activity, acting on peroxide as acceptor
GO_0140311Molecular functionprotein sequestering activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSESN2
Protein nameSestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)
SynonymsHi95
SEST2
DescriptionFUNCTION: Functions as an intracellular leucine sensor that negatively regulates the mTORC1 signaling pathway through the GATOR complex . In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents mTORC1 signaling . Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway . This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via mTORC1 . May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 . May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress . Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein . Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 . However, this could not be confirmed . .

AccessionsENST00000253063.4
P58004
ENST00000645231.2