Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 9 studies | 24% ± 10% | |
| conventional dendritic cell | 9 studies | 26% ± 15% | |
| dendritic cell | 6 studies | 32% ± 15% | |
| plasma cell | 4 studies | 35% ± 9% | |
| plasmablast | 4 studies | 44% ± 23% | |
| macrophage | 4 studies | 25% ± 8% | |
| non-classical monocyte | 3 studies | 26% ± 6% | |
| myeloid cell | 3 studies | 19% ± 2% | |
| germinal center B cell | 3 studies | 24% ± 5% | |
| astrocyte | 3 studies | 24% ± 8% | |
| glutamatergic neuron | 3 studies | 24% ± 6% |
Insufficient scRNA-seq data for expression of SEMA4A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4076.78 | 652 / 653 | 98% | 32.28 | 591 / 605 |
| prostate | 97% | 2742.66 | 238 / 245 | 100% | 36.15 | 502 / 502 |
| lung | 99% | 2358.09 | 573 / 578 | 96% | 27.66 | 1105 / 1155 |
| breast | 68% | 983.97 | 314 / 459 | 98% | 23.67 | 1091 / 1118 |
| ovary | 74% | 689.23 | 134 / 180 | 90% | 13.83 | 388 / 430 |
| kidney | 94% | 1675.92 | 84 / 89 | 70% | 7.31 | 633 / 901 |
| brain | 88% | 2041.61 | 2324 / 2642 | 73% | 8.22 | 514 / 705 |
| stomach | 82% | 804.14 | 293 / 359 | 77% | 8.43 | 219 / 286 |
| uterus | 68% | 640.88 | 115 / 170 | 88% | 20.31 | 406 / 459 |
| bladder | 62% | 1002.62 | 13 / 21 | 90% | 19.44 | 452 / 504 |
| skin | 72% | 3006.87 | 1305 / 1809 | 72% | 8.51 | 338 / 472 |
| esophagus | 50% | 1747.16 | 719 / 1445 | 92% | 23.07 | 168 / 183 |
| intestine | 50% | 473.91 | 483 / 966 | 78% | 7.92 | 413 / 527 |
| pancreas | 16% | 116.55 | 54 / 328 | 89% | 9.88 | 159 / 178 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 114.51 | 29 / 29 |
| peripheral blood | 100% | 12783.88 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4148.40 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 31.15 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.80 | 1 / 1 |
| eye | 0% | 0 | 0 / 0 | 69% | 4.83 | 55 / 80 |
| adipose | 52% | 567.03 | 631 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 49% | 405.42 | 659 / 1335 | 0% | 0 | 0 / 0 |
| liver | 4% | 27.02 | 8 / 226 | 13% | 1.30 | 54 / 406 |
| muscle | 14% | 98.61 | 114 / 803 | 0% | 0 | 0 / 0 |
| heart | 11% | 71.12 | 91 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 1% | 7.58 | 3 / 258 | 3% | 0.21 | 6 / 230 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0001525 | Biological process | angiogenesis |
| GO_1904891 | Biological process | positive regulation of excitatory synapse assembly |
| GO_0010594 | Biological process | regulation of endothelial cell migration |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_1905704 | Biological process | positive regulation of inhibitory synapse assembly |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0045063 | Biological process | T-helper 1 cell differentiation |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0007411 | Biological process | axon guidance |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045499 | Molecular function | chemorepellent activity |
| GO_0030215 | Molecular function | semaphorin receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SEMA4A |
| Protein name | Semaphorin-4A (Semaphorin-B) (Sema B) Semaphorin 4A |
| Synonyms | SEMAB SEMB UNQ783/PRO1317 |
| Description | FUNCTION: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). . |
| Accessions | ENST00000355014.6 [Q9H3S1-1] Q5TCI6 ENST00000435124.5 ENST00000633494.1 A0A0J9YVY6 ENST00000368284.5 [Q9H3S1-2] ENST00000438830.5 ENST00000414683.5 Q9H3S1 Q5TCI4 ENST00000368282.1 [Q9H3S1-1] ENST00000368285.8 [Q9H3S1-1] Q5TCJ7 |
