SEMA3A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	21 studies	41% ± 20%	Explore
glutamatergic neuron	10 studies	33% ± 16%	Explore
astrocyte	8 studies	35% ± 21%	Explore
adipocyte	7 studies	42% ± 14%	Explore
neuron	5 studies	28% ± 15%	Explore
amacrine cell	5 studies	42% ± 28%	Explore
retinal rod cell	5 studies	51% ± 24%	Explore
pericyte	4 studies	29% ± 19%	Explore
epithelial cell	4 studies	29% ± 13%	Explore
GABAergic neuron	4 studies	32% ± 12%	Explore
connective tissue cell	4 studies	20% ± 2%	Explore
myofibroblast cell	4 studies	28% ± 9%	Explore
ciliated cell	4 studies	18% ± 2%	Explore
smooth muscle cell	3 studies	36% ± 15%	Explore
mesothelial cell	3 studies	29% ± 10%	Explore
GABAergic amacrine cell	3 studies	23% ± 8%	Explore
Mueller cell	3 studies	43% ± 15%	Explore
glycinergic amacrine cell	3 studies	72% ± 12%	Explore
retinal ganglion cell	3 studies	38% ± 17%	Explore
fibroblast	3 studies	22% ± 9%	Explore
interneuron	3 studies	29% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	27% ± 14%	Explore
eye	5 studies	35% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	815.36	570 / 578	88%	7.62	1011 / 1155
intestine	96%	2214.40	932 / 966	85%	5.36	447 / 527
esophagus	85%	2040.62	1224 / 1445	87%	7.21	159 / 183
bladder	100%	1920.95	21 / 21	68%	3.51	341 / 504
thymus	98%	687.94	639 / 653	52%	1.45	317 / 605
stomach	60%	637.99	216 / 359	87%	5.79	248 / 286
breast	89%	468.62	408 / 459	46%	1.07	511 / 1118
skin	69%	552.00	1250 / 1809	58%	11.21	275 / 472
brain	56%	309.75	1486 / 2642	61%	3.72	431 / 705
ovary	24%	80.48	44 / 180	82%	6.06	352 / 430
prostate	71%	356.17	175 / 245	34%	0.71	170 / 502
spleen	100%	1181.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.78	1 / 1
adipose	97%	748.23	1171 / 1204	0%	0	0 / 0
uterus	30%	105.42	51 / 170	59%	5.97	271 / 459
pancreas	0%	0.80	1 / 328	84%	4.06	149 / 178
lymph node	0%	0	0 / 0	69%	1.31	20 / 29
heart	39%	135.97	332 / 861	0%	0	0 / 0
kidney	16%	56.88	14 / 89	22%	1.14	195 / 901
tonsil	0%	0	0 / 0	36%	1.52	16 / 45
blood vessel	17%	66.81	230 / 1335	0%	0	0 / 0
adrenal gland	9%	28.81	22 / 258	8%	0.62	18 / 230
liver	1%	2.07	2 / 226	11%	0.47	46 / 406
eye	0%	0	0 / 0	4%	0.16	3 / 80
muscle	1%	2.37	8 / 803	0%	0	0 / 0
peripheral blood	0%	0.19	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1901166	Biological process	neural crest cell migration involved in autonomic nervous system development
GO_0097491	Biological process	sympathetic neuron projection guidance
GO_0048485	Biological process	sympathetic nervous system development
GO_0001755	Biological process	neural crest cell migration
GO_0021675	Biological process	nerve development
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0060385	Biological process	axonogenesis involved in innervation
GO_0150020	Biological process	basal dendrite arborization
GO_0021612	Biological process	facial nerve structural organization
GO_0001764	Biological process	neuron migration
GO_0048846	Biological process	axon extension involved in axon guidance
GO_0021772	Biological process	olfactory bulb development
GO_0048841	Biological process	regulation of axon extension involved in axon guidance
GO_0050919	Biological process	negative chemotaxis
GO_0021637	Biological process	trigeminal nerve structural organization
GO_0061549	Biological process	sympathetic ganglion development
GO_0021785	Biological process	branchiomotor neuron axon guidance
GO_0010977	Biological process	negative regulation of neuron projection development
GO_0030335	Biological process	positive regulation of cell migration
GO_0097490	Biological process	sympathetic neuron projection extension
GO_0030517	Biological process	negative regulation of axon extension
GO_0008045	Biological process	motor neuron axon guidance
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0048880	Biological process	sensory system development
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0030425	Cellular component	dendrite
GO_0030424	Cellular component	axon
GO_0030215	Molecular function	semaphorin receptor binding
GO_0045499	Molecular function	chemorepellent activity
GO_0038191	Molecular function	neuropilin binding

IV. Literature review

[source]

Gene name	SEMA3A
Protein name	Semaphorin 3A Uncharacterized protein SEMA3A Semaphorin-3A (Semaphorin III) (Sema III)
Synonyms	SEMAD
Description	FUNCTION: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. .
Accessions	Q14563 ENST00000265362.9 Q86UJ2 ENST00000424555.5 Q75MQ2 C9JD25 ENST00000448879.5 A0A0C4DG50 ENST00000436949.5 C9J9C4 ENST00000420047.1

SEMA3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review