SCN2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	13 studies	39% ± 18%	Explore
glutamatergic neuron	12 studies	72% ± 21%	Explore
GABAergic neuron	11 studies	57% ± 26%	Explore
retinal ganglion cell	7 studies	43% ± 18%	Explore
neuron	6 studies	39% ± 17%	Explore
interneuron	6 studies	64% ± 26%	Explore
endothelial cell	5 studies	37% ± 22%	Explore
amacrine cell	5 studies	33% ± 12%	Explore
retinal cone cell	5 studies	33% ± 17%	Explore
granule cell	4 studies	63% ± 24%	Explore
GABAergic interneuron	3 studies	69% ± 6%	Explore
retinal bipolar neuron	3 studies	23% ± 4%	Explore
GABAergic amacrine cell	3 studies	44% ± 13%	Explore
OFF-bipolar cell	3 studies	28% ± 13%	Explore
ON-bipolar cell	3 studies	26% ± 11%	Explore
glycinergic amacrine cell	3 studies	38% ± 10%	Explore
rod bipolar cell	3 studies	24% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	46% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	44% ± 24%	Explore
kidney	3 studies	24% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	10347.52	2577 / 2642	93%	6.32	656 / 705
kidney	100%	1673.67	89 / 89	13%	0.44	115 / 901
ureter	0%	0	0 / 0	100%	2.40	1 / 1
adrenal gland	16%	136.95	41 / 258	66%	3.54	152 / 230
uterus	22%	114.70	38 / 170	18%	0.50	82 / 459
breast	14%	110.10	62 / 459	8%	0.20	88 / 1118
esophagus	1%	2.43	8 / 1445	14%	0.58	25 / 183
stomach	5%	24.11	17 / 359	7%	0.15	20 / 286
lung	0%	0	0 / 578	10%	0.40	121 / 1155
ovary	2%	8.63	3 / 180	7%	0.13	28 / 430
pancreas	0%	0	0 / 328	7%	0.15	13 / 178
bladder	0%	0	0 / 21	7%	0.16	33 / 504
skin	1%	6.34	20 / 1809	5%	0.11	24 / 472
prostate	2%	9.94	4 / 245	4%	0.07	22 / 502
intestine	0%	1.70	3 / 966	4%	0.09	19 / 527
adipose	4%	18.49	43 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.15	1 / 29
blood vessel	3%	12.30	34 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.01	1 / 80
liver	0%	0	0 / 226	1%	0.02	5 / 406
thymus	0%	0	0 / 653	1%	0.02	7 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45

III. Associated gene sets

GO_0086002	Biological process	cardiac muscle cell action potential involved in contraction
GO_0042552	Biological process	myelination
GO_0021675	Biological process	nerve development
GO_0008340	Biological process	determination of adult lifespan
GO_0021542	Biological process	dentate gyrus development
GO_0008627	Biological process	intrinsic apoptotic signaling pathway in response to osmotic stress
GO_0051402	Biological process	neuron apoptotic process
GO_0006814	Biological process	sodium ion transport
GO_0019228	Biological process	neuronal action potential
GO_0007613	Biological process	memory
GO_0007399	Biological process	nervous system development
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0071456	Biological process	cellular response to hypoxia
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0030315	Cellular component	T-tubule
GO_0033270	Cellular component	paranode region of axon
GO_0033268	Cellular component	node of Ranvier
GO_0001518	Cellular component	voltage-gated sodium channel complex
GO_0030424	Cellular component	axon
GO_0014704	Cellular component	intercalated disc
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SCN2A
Protein name	Sodium voltage-gated channel alpha subunit 2 Sodium channel protein Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
Synonyms	SCN2A2 NAC2 HBA SCN2A1
Description	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient . Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity). . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .
Accessions	ENST00000636384.2 ENST00000283256.10 [Q99250-1] ENST00000673831.1 A0A669KBL5 A0A669KAR0 ENST00000636985.2 A0A1B0GWA6 ENST00000637266.2 [Q99250-1] A0A1B0GW67 ENST00000636135.1 F6U291 Q99250 ENST00000673883.1 ENST00000424833.5 A0A0D9SGG2 ENST00000636662.2 A0A669KBM3 A0A1B0GW40 ENST00000631182.3 [Q99250-2] ENST00000636769.1 A0A1B0GTX0 ENST00000486878.2 ENST00000375437.7 [Q99250-1] ENST00000674133.1 A0A1B0GTS6 ENST00000637367.1 ENST00000636071.2 [Q99250-2]

SCN2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review