Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| platelet | 8 studies | 23% ± 3% | |
| retinal ganglion cell | 5 studies | 78% ± 26% | |
| GABAergic neuron | 5 studies | 28% ± 10% | |
| glutamatergic neuron | 5 studies | 31% ± 15% | |
| neuron | 3 studies | 23% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 22% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 9283.14 | 2574 / 2642 | 98% | 12.80 | 690 / 705 |
| breast | 81% | 1271.88 | 371 / 459 | 70% | 3.74 | 784 / 1118 |
| thymus | 53% | 696.40 | 343 / 653 | 87% | 8.90 | 526 / 605 |
| adrenal gland | 57% | 833.45 | 148 / 258 | 70% | 3.98 | 160 / 230 |
| kidney | 16% | 232.69 | 14 / 89 | 90% | 7.68 | 813 / 901 |
| lung | 48% | 678.19 | 279 / 578 | 57% | 2.65 | 657 / 1155 |
| prostate | 27% | 387.67 | 65 / 245 | 77% | 3.34 | 389 / 502 |
| muscle | 100% | 24606.66 | 803 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 20% | 271.42 | 67 / 328 | 79% | 4.17 | 140 / 178 |
| heart | 92% | 3862.52 | 794 / 861 | 0% | 0 | 0 / 0 |
| adipose | 90% | 1602.18 | 1088 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 90% | 1627.79 | 217 / 241 | 0% | 0 | 0 / 0 |
| bladder | 62% | 877.14 | 13 / 21 | 23% | 1.27 | 118 / 504 |
| skin | 6% | 95.98 | 111 / 1809 | 79% | 7.21 | 371 / 472 |
| uterus | 46% | 610.68 | 78 / 170 | 35% | 2.14 | 159 / 459 |
| esophagus | 44% | 655.92 | 632 / 1445 | 24% | 0.96 | 44 / 183 |
| liver | 8% | 98.71 | 18 / 226 | 59% | 2.88 | 238 / 406 |
| eye | 0% | 0 | 0 / 0 | 66% | 4.97 | 53 / 80 |
| ovary | 18% | 242.83 | 32 / 180 | 36% | 1.35 | 153 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 52% | 1.67 | 15 / 29 |
| blood vessel | 51% | 745.01 | 682 / 1335 | 0% | 0 | 0 / 0 |
| intestine | 31% | 399.21 | 297 / 966 | 15% | 0.66 | 81 / 527 |
| stomach | 17% | 217.26 | 60 / 359 | 27% | 1.06 | 77 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.97 | 7 / 45 |
| peripheral blood | 16% | 213.66 | 144 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0086012 | Biological process | membrane depolarization during cardiac muscle cell action potential |
| GO_2000649 | Biological process | regulation of sodium ion transmembrane transporter activity |
| GO_0060307 | Biological process | regulation of ventricular cardiac muscle cell membrane repolarization |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0086002 | Biological process | cardiac muscle cell action potential involved in contraction |
| GO_0086047 | Biological process | membrane depolarization during Purkinje myocyte cell action potential |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0040011 | Biological process | locomotion |
| GO_0007155 | Biological process | cell adhesion |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0021966 | Biological process | corticospinal neuron axon guidance |
| GO_1905152 | Biological process | positive regulation of voltage-gated sodium channel activity |
| GO_0010765 | Biological process | positive regulation of sodium ion transport |
| GO_0060371 | Biological process | regulation of atrial cardiac muscle cell membrane depolarization |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0061337 | Biological process | cardiac conduction |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0007411 | Biological process | axon guidance |
| GO_0019227 | Biological process | neuronal action potential propagation |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0014704 | Cellular component | intercalated disc |
| GO_0043204 | Cellular component | perikaryon |
| GO_0030315 | Cellular component | T-tubule |
| GO_0033268 | Cellular component | node of Ranvier |
| GO_0001518 | Cellular component | voltage-gated sodium channel complex |
| GO_0086006 | Molecular function | voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
| GO_0005248 | Molecular function | voltage-gated sodium channel activity |
| GO_0019871 | Molecular function | sodium channel inhibitor activity |
| GO_0086062 | Molecular function | voltage-gated sodium channel activity involved in Purkinje myocyte action potential |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0017080 | Molecular function | sodium channel regulator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SCN1B |
| Protein name | Sodium voltage-gated channel beta subunit 1 (cDNA FLJ55064, moderately similar to Sodium channel beta-1 subunit) Sodium channel subunit beta-1 |
| Synonyms | |
| Description | FUNCTION: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. .; FUNCTION: [Isoform 2]: Cell adhesion molecule that plays a critical role in neuronal migration and pathfinding during brain development. Stimulates neurite outgrowth . Has no regulatory function on the SCN2A sodium channel complex . . |
| Accessions | ENST00000675741.1 A0A1W2PR05 ENST00000415950.5 [Q07699-2] ENST00000638536.1 [Q07699-1] ENST00000640135.1 Q07699 Q2KHR9 B4DI92 A0A6Q8PHF7 ENST00000676410.1 ENST00000262631.11 [Q07699-1] A0A6Q8PGS1 A0A1W2PS68 ENST00000595652.5 Q8WU42 ENST00000596348.2 |
