SCD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006636Biological processunsaturated fatty acid biosynthetic process
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_1903966Biological processmonounsaturated fatty acid biosynthetic process
GO_0070542Biological processresponse to fatty acid
GO_0005730Cellular componentnucleolus
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016491Molecular functionoxidoreductase activity
GO_0005506Molecular functioniron ion binding
GO_0005515Molecular functionprotein binding
GO_0032896Molecular functionpalmitoyl-CoA 9-desaturase activity
GO_0004768Molecular functionstearoyl-CoA 9-desaturase activity

IV. Literature review

[source]
Gene nameSCD
Protein nameStearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase)
SynonymsSCD1
SCDOS
FADS5
DescriptionFUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates . Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA . Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids . Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity). .

AccessionsENST00000370355.3
O00767