SCARB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	23 studies	31% ± 11%	Explore
microglial cell	7 studies	27% ± 9%	Explore
macrophage	7 studies	28% ± 6%	Explore
capillary endothelial cell	5 studies	29% ± 9%	Explore
myeloid cell	5 studies	19% ± 2%	Explore
Mueller cell	5 studies	32% ± 9%	Explore
hepatocyte	5 studies	49% ± 25%	Explore
astrocyte	5 studies	22% ± 4%	Explore
pericyte	4 studies	24% ± 5%	Explore
retinal pigment epithelial cell	4 studies	29% ± 13%	Explore
GABAergic neuron	4 studies	34% ± 14%	Explore
epithelial cell	3 studies	29% ± 8%	Explore
endothelial cell of vascular tree	3 studies	25% ± 1%	Explore
glutamatergic neuron	3 studies	42% ± 14%	Explore
dendritic cell	3 studies	18% ± 3%	Explore
melanocyte	3 studies	38% ± 14%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 2%	Explore
oligodendrocyte	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	27% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	18404.91	226 / 226	100%	112.43	404 / 406
adrenal gland	100%	144800.91	258 / 258	99%	334.12	228 / 230
brain	100%	3712.16	2633 / 2642	99%	33.99	701 / 705
prostate	98%	2211.84	241 / 245	99%	28.14	496 / 502
breast	100%	8578.35	459 / 459	96%	36.20	1074 / 1118
skin	98%	2976.80	1765 / 1809	98%	92.44	461 / 472
intestine	90%	1808.93	873 / 966	96%	41.12	507 / 527
uterus	99%	2709.95	169 / 170	82%	19.57	377 / 459
bladder	95%	1878.14	20 / 21	84%	26.36	421 / 504
ovary	100%	9434.68	180 / 180	78%	16.30	337 / 430
lung	93%	2435.12	535 / 578	83%	19.17	954 / 1155
esophagus	84%	1265.11	1209 / 1445	86%	24.54	157 / 183
stomach	70%	892.51	252 / 359	94%	36.88	269 / 286
thymus	97%	1946.89	634 / 653	67%	11.54	406 / 605
kidney	56%	713.87	50 / 89	87%	65.56	785 / 901
pancreas	51%	575.57	168 / 328	90%	19.56	161 / 178
adipose	100%	8425.85	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	97.41	80 / 80
lymph node	0%	0	0 / 0	100%	35.81	29 / 29
ureter	0%	0	0 / 0	100%	11.73	1 / 1
spleen	100%	2179.20	240 / 241	0%	0	0 / 0
heart	60%	847.45	519 / 861	0%	0	0 / 0
blood vessel	56%	936.70	750 / 1335	0%	0	0 / 0
muscle	54%	621.55	432 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	49%	9.06	22 / 45
peripheral blood	23%	2480.13	215 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070328	Biological process	triglyceride homeostasis
GO_0031663	Biological process	lipopolysaccharide-mediated signaling pathway
GO_0015914	Biological process	phospholipid transport
GO_0034381	Biological process	plasma lipoprotein particle clearance
GO_0010886	Biological process	positive regulation of cholesterol storage
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0043691	Biological process	reverse cholesterol transport
GO_0010867	Biological process	positive regulation of triglyceride biosynthetic process
GO_0034375	Biological process	high-density lipoprotein particle remodeling
GO_0042060	Biological process	wound healing
GO_0043534	Biological process	blood vessel endothelial cell migration
GO_0046718	Biological process	symbiont entry into host cell
GO_0034384	Biological process	high-density lipoprotein particle clearance
GO_0070508	Biological process	cholesterol import
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0001935	Biological process	endothelial cell proliferation
GO_0044406	Biological process	adhesion of symbiont to host
GO_0098856	Biological process	intestinal lipid absorption
GO_0035461	Biological process	vitamin transmembrane transport
GO_0050764	Biological process	regulation of phagocytosis
GO_0033344	Biological process	cholesterol efflux
GO_0051000	Biological process	positive regulation of nitric-oxide synthase activity
GO_0010899	Biological process	regulation of phosphatidylcholine catabolic process
GO_0032497	Biological process	detection of lipopolysaccharide
GO_0043654	Biological process	recognition of apoptotic cell
GO_0046867	Biological process	carotenoid transport
GO_0015920	Biological process	lipopolysaccharide transport
GO_0042632	Biological process	cholesterol homeostasis
GO_0006707	Biological process	cholesterol catabolic process
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005901	Cellular component	caveola
GO_0005765	Cellular component	lysosomal membrane
GO_0008289	Molecular function	lipid binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0070506	Molecular function	high-density lipoprotein particle receptor activity
GO_0001618	Molecular function	virus receptor activity
GO_0005044	Molecular function	scavenger receptor activity
GO_0034185	Molecular function	apolipoprotein binding
GO_0005545	Molecular function	1-phosphatidylinositol binding
GO_0030169	Molecular function	low-density lipoprotein particle binding
GO_0001875	Molecular function	lipopolysaccharide immune receptor activity
GO_0034186	Molecular function	apolipoprotein A-I binding
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0008035	Molecular function	high-density lipoprotein particle binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SCARB1
Protein name	Scavenger receptor class B member 1 Scavenger receptor class B member 1 (SR-BI) Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)
Synonyms	CD36L1 CLA1
Description	FUNCTION: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells . Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux . Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity . .; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry . Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate . .; FUNCTION: (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. .; FUNCTION: (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. .
Accessions	ENST00000415380.6 [Q8WTV0-1] ENST00000680556.1 F5H4X0 B7ZKQ9 A0A0S2Z3I2 ENST00000681686.1 A0A7P0T9B3 ENST00000544327.1 ENST00000339570.9 [Q8WTV0-5] ENST00000545493.1 ENST00000679605.1 A0A7P0T9I2 A0A7P0Z4E3 ENST00000680596.1 F5H5E8 ENST00000681117.1 A0A7P0T913 ENST00000680926.1 ENST00000261693.11 [Q8WTV0-2] ENST00000680982.1 ENST00000546215.5 A0A7P0Z4J8 A0A0S2Z3N2 Q8WTV0

SCARB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review