SAV1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0030216Biological processkeratinocyte differentiation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0035329Biological processhippo signaling
GO_0060044Biological processnegative regulation of cardiac muscle cell proliferation
GO_1902174Biological processpositive regulation of keratinocyte apoptotic process
GO_2000036Biological processregulation of stem cell population maintenance
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0097283Biological processkeratinocyte apoptotic process
GO_0060038Biological processcardiac muscle cell proliferation
GO_0050821Biological processprotein stabilization
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0060412Biological processventricular septum morphogenesis
GO_0001942Biological processhair follicle development
GO_0060575Biological processintestinal epithelial cell differentiation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0060487Biological processlung epithelial cell differentiation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0060090Molecular functionmolecular adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSAV1
Protein nameProtein salvador homolog 1 (45 kDa WW domain protein) (hWW45)
Salvador family WW domain containing protein 1
SynonymsWW45
DescriptionFUNCTION: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. .

AccessionsH0YJT4
ENST00000557458.1
H0YJH0
H0YJ02
ENST00000324679.5
ENST00000553731.1
ENST00000555720.5
Q9H4B6
G3V453
ENST00000556735.1