SART3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0000244Biological processspliceosomal tri-snRNP complex assembly
GO_0140673Biological processtranscription elongation-coupled chromatin remodeling
GO_0000387Biological processspliceosomal snRNP assembly
GO_0048872Biological processhomeostasis of number of cells
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0006334Biological processnucleosome assembly
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000902Biological processcell morphogenesis
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0005691Cellular componentU6atac snRNP
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071002Cellular componentU4atac/U6atac snRNP
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0071001Cellular componentU4/U6 snRNP
GO_0061574Cellular componentASAP complex
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0030624Molecular functionU6atac snRNA binding
GO_0017070Molecular functionU6 snRNA binding
GO_0003723Molecular functionRNA binding
GO_0030621Molecular functionU4 snRNA binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameSART3
Protein nameSpliceosome associated factor 3, U4/U6 recycling protein
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
SynonymsKIAA0156
TIP110
DescriptionFUNCTION: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation . Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites . May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly . May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair . May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity). .; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. .

AccessionsENST00000546728.5 [Q15020-2]
ENST00000651280.1
ENST00000547397.1
A0A494C0L2
ENST00000431469.6 [Q15020-4]
ENST00000546611.1 [Q15020-3]
A0A499FI31
ENST00000550619.1
F8W667
ENST00000547528.5
ENST00000546815.6 [Q15020-1]
ENST00000550322.5
F8VZM2
Q15020
ENST00000228284.8
H0YHU8
F8VVK9