RTN2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RTN2 at tissue level.

III. Associated gene sets

GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0065002Biological processintracellular protein transmembrane transport
GO_0010467Biological processgene expression
GO_0046324Biological processregulation of glucose import
GO_0014802Cellular componentterminal cisterna
GO_0009986Cellular componentcell surface
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0030315Cellular componentT-tubule
GO_0005783Cellular componentendoplasmic reticulum
GO_0030018Cellular componentZ disc
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005882Cellular componentintermediate filament
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRTN2
Protein nameReticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)
Truncated RTN2-A2
Reticulon 2 (Truncated RTN2-B2)
Reticulon
SynonymsNSPL1
hCG_1996624
DescriptionFUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity . Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity). Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity). .

AccessionsQ6GMT0
ENST00000591286.5
ENST00000590526.5
ENST00000430715.6 [O75298-3]
ENST00000587597.5
Q7RTN0
K7EMR7
ENST00000245923.9 [O75298-1]
Q96CG9
O75298
Q7RTM9
ENST00000344680.8 [O75298-2]