RTEL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RTEL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RTEL1 at tissue level.

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_1902990Biological processmitotic telomere maintenance via semi-conservative replication
GO_0006281Biological processDNA repair
GO_1904506Biological processnegative regulation of telomere maintenance in response to DNA damage
GO_1904355Biological processpositive regulation of telomere capping
GO_0090657Biological processtelomeric loop disassembly
GO_0000732Biological processDNA strand displacement
GO_0031297Biological processreplication fork processing
GO_0032206Biological processpositive regulation of telomere maintenance
GO_1904430Biological processnegative regulation of t-circle formation
GO_0000723Biological processtelomere maintenance
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_1904358Biological processpositive regulation of telomere maintenance via telomere lengthening
GO_1904535Biological processpositive regulation of telomeric loop disassembly
GO_0045910Biological processnegative regulation of DNA recombination
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0070182Molecular functionDNA polymerase binding
GO_0003678Molecular functionDNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRTEL1
Protein nameRegulator of telomere elongation helicase 1 (EC 3.6.4.12)
Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like)
Regulator of telomere elongation helicase 1
SynonymsNHL
KIAA1088
C20orf41
DescriptionFUNCTION: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. .

FUNCTION: ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. .

AccessionsENST00000684971.1
ENST00000482936.6 [Q9NZ71-8]
A0A2R8YD56
ENST00000692658.1
ENST00000508582.7 [Q9NZ71-7]
ENST00000646389.1
R4IXY3
X6R5I7
ENST00000360203.11 [Q9NZ71-6]
ENST00000469728.5
A0A0C4DGC7
ENST00000496816.5
Q9NZ71
ENST00000318100.9 [Q9NZ71-9]
A0A2R8Y7H5
A0A8V8TLQ6
A0A8V8TLB5
ENST00000356810.5
ENST00000687123.1
ENST00000370018.7 [Q9NZ71-1]