Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 32% ± 10% | |
| macrophage | 5 studies | 19% ± 4% | |
| oligodendrocyte | 5 studies | 19% ± 2% | |
| natural killer cell | 4 studies | 18% ± 2% | |
| CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 3% | |
| classical monocyte | 3 studies | 21% ± 4% | |
| non-classical monocyte | 3 studies | 24% ± 6% | |
| endothelial cell | 3 studies | 24% ± 2% | |
| ciliated cell | 3 studies | 24% ± 4% | |
| regulatory T cell | 3 studies | 17% ± 1% | |
| fibroblast | 3 studies | 19% ± 5% | |
| GABAergic neuron | 3 studies | 31% ± 2% | |
| glutamatergic neuron | 3 studies | 40% ± 5% | |
| dendritic cell | 3 studies | 27% ± 9% | |
| basal cell | 3 studies | 27% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1600.11 | 459 / 459 | 100% | 42.02 | 1118 / 1118 |
| esophagus | 100% | 1544.08 | 1445 / 1445 | 100% | 34.58 | 183 / 183 |
| intestine | 100% | 1684.21 | 966 / 966 | 100% | 38.43 | 527 / 527 |
| liver | 100% | 1045.35 | 226 / 226 | 100% | 24.81 | 406 / 406 |
| ovary | 100% | 1078.65 | 180 / 180 | 100% | 28.78 | 430 / 430 |
| pancreas | 100% | 1326.19 | 328 / 328 | 100% | 33.47 | 178 / 178 |
| prostate | 100% | 1660.96 | 245 / 245 | 100% | 44.54 | 502 / 502 |
| stomach | 100% | 1574.75 | 359 / 359 | 100% | 37.18 | 286 / 286 |
| uterus | 100% | 1262.50 | 170 / 170 | 100% | 40.01 | 459 / 459 |
| kidney | 100% | 2228.99 | 89 / 89 | 100% | 32.42 | 900 / 901 |
| thymus | 100% | 1341.17 | 653 / 653 | 100% | 32.13 | 604 / 605 |
| brain | 100% | 1589.17 | 2637 / 2642 | 100% | 31.42 | 705 / 705 |
| bladder | 100% | 1518.24 | 21 / 21 | 100% | 38.87 | 503 / 504 |
| lung | 100% | 1558.89 | 576 / 578 | 100% | 36.62 | 1155 / 1155 |
| skin | 100% | 1876.96 | 1809 / 1809 | 99% | 38.87 | 469 / 472 |
| adrenal gland | 100% | 1995.46 | 258 / 258 | 99% | 25.98 | 227 / 230 |
| adipose | 100% | 1686.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 42.72 | 29 / 29 |
| muscle | 100% | 1916.91 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2201.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 34.27 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.34 | 1 / 1 |
| blood vessel | 100% | 1408.37 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1587.97 | 846 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 92% | 1302.07 | 859 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 86% | 16.59 | 69 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1905592 | Biological process | negative regulation of optical nerve axon regeneration |
| GO_0006396 | Biological process | RNA processing |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003963 | Molecular function | RNA-3'-phosphate cyclase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | RTCA |
| Protein name | RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1) RNA 3'-terminal phosphate cyclase |
| Synonyms | RTCD1 RPC1 RTC1 RPC |
| Description | FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA . The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product . Likely functions in some aspects of cellular RNA processing . Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury . . |
| Accessions | ENST00000370126.1 ENST00000260563.4 [O00442-2] O00442 ENST00000370128.9 [O00442-1] A6NIC1 |