Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 5 studies | 32% ± 10% | |
macrophage | 5 studies | 19% ± 4% | |
oligodendrocyte | 5 studies | 19% ± 2% | |
natural killer cell | 4 studies | 18% ± 2% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 3% | |
classical monocyte | 3 studies | 21% ± 4% | |
non-classical monocyte | 3 studies | 24% ± 6% | |
endothelial cell | 3 studies | 24% ± 2% | |
ciliated cell | 3 studies | 24% ± 4% | |
regulatory T cell | 3 studies | 17% ± 1% | |
fibroblast | 3 studies | 19% ± 5% | |
GABAergic neuron | 3 studies | 31% ± 2% | |
glutamatergic neuron | 3 studies | 40% ± 5% | |
dendritic cell | 3 studies | 27% ± 9% | |
basal cell | 3 studies | 27% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 1600.11 | 459 / 459 | 100% | 42.02 | 1118 / 1118 |
esophagus | 100% | 1544.08 | 1445 / 1445 | 100% | 34.58 | 183 / 183 |
intestine | 100% | 1684.21 | 966 / 966 | 100% | 38.43 | 527 / 527 |
liver | 100% | 1045.35 | 226 / 226 | 100% | 24.81 | 406 / 406 |
ovary | 100% | 1078.65 | 180 / 180 | 100% | 28.78 | 430 / 430 |
pancreas | 100% | 1326.19 | 328 / 328 | 100% | 33.47 | 178 / 178 |
prostate | 100% | 1660.96 | 245 / 245 | 100% | 44.54 | 502 / 502 |
stomach | 100% | 1574.75 | 359 / 359 | 100% | 37.18 | 286 / 286 |
uterus | 100% | 1262.50 | 170 / 170 | 100% | 40.01 | 459 / 459 |
kidney | 100% | 2228.99 | 89 / 89 | 100% | 32.42 | 900 / 901 |
thymus | 100% | 1341.17 | 653 / 653 | 100% | 32.13 | 604 / 605 |
brain | 100% | 1589.17 | 2637 / 2642 | 100% | 31.42 | 705 / 705 |
bladder | 100% | 1518.24 | 21 / 21 | 100% | 38.87 | 503 / 504 |
lung | 100% | 1558.89 | 576 / 578 | 100% | 36.62 | 1155 / 1155 |
skin | 100% | 1876.96 | 1809 / 1809 | 99% | 38.87 | 469 / 472 |
adrenal gland | 100% | 1995.46 | 258 / 258 | 99% | 25.98 | 227 / 230 |
adipose | 100% | 1686.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 42.72 | 29 / 29 |
muscle | 100% | 1916.91 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2201.20 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 34.27 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.34 | 1 / 1 |
blood vessel | 100% | 1408.37 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 98% | 1587.97 | 846 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 1302.07 | 859 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 16.59 | 69 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1905592 | Biological process | negative regulation of optical nerve axon regeneration |
GO_0006396 | Biological process | RNA processing |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003963 | Molecular function | RNA-3'-phosphate cyclase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | RTCA |
Protein name | RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1) RNA 3'-terminal phosphate cyclase |
Synonyms | RTCD1 RPC1 RTC1 RPC |
Description | FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA . The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product . Likely functions in some aspects of cellular RNA processing . Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury . . |
Accessions | ENST00000370126.1 ENST00000260563.4 [O00442-2] O00442 ENST00000370128.9 [O00442-1] A6NIC1 |