RTCA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905592Biological processnegative regulation of optical nerve axon regeneration
GO_0006396Biological processRNA processing
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003963Molecular functionRNA-3'-phosphate cyclase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRTCA
Protein nameRNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) (RTC domain-containing protein 1)
RNA 3'-terminal phosphate cyclase
SynonymsRTCD1
RPC1
RTC1
RPC
DescriptionFUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA . The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product . Likely functions in some aspects of cellular RNA processing . Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury . .

AccessionsENST00000370126.1
ENST00000260563.4 [O00442-2]
O00442
ENST00000370128.9 [O00442-1]
A6NIC1