RRP8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RRP8 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0042149Biological processcellular response to glucose starvation
GO_0045786Biological processnegative regulation of cell cycle
GO_0032259Biological processmethylation
GO_0000183Biological processrDNA heterochromatin formation
GO_0046015Biological processregulation of transcription by glucose
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_1903450Biological processregulation of G1 to G0 transition
GO_0006364Biological processrRNA processing
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0061773Cellular componenteNoSc complex
GO_0005654Cellular componentnucleoplasm
GO_0005677Cellular componentchromatin silencing complex
GO_0005829Cellular componentcytosol
GO_0033553Cellular componentrDNA heterochromatin
GO_0035064Molecular functionmethylated histone binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0008757Molecular functionS-adenosylmethionine-dependent methyltransferase activity

IV. Literature review

[source]
Gene nameRRP8
Protein nameRibosomal RNA-processing protein 8 (EC 2.1.1.-)
Ribosomal RNA processing 8
Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)
SynonymsNML
hucep-1
KIAA0409
DescriptionFUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. .

FUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. .

FUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. .

AccessionsENST00000530762.1
O43159
E9PPY3
E9PS87
ENST00000254605.11
E9PPP6
ENST00000533907.1
ENST00000534343.1