RPUSD3 | OmnibusX

Name	Number of supported studies	Average coverage
hematopoietic precursor cell	4 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	20% ± 5%	Explore
epithelial cell	4 studies	26% ± 8%	Explore
natural killer cell	4 studies	21% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	20% ± 3%	Explore
erythroblast	3 studies	25% ± 10%	Explore
dendritic cell	3 studies	21% ± 3%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RPUSD3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1436.76	21 / 21	100%	22.32	504 / 504
esophagus	100%	1500.71	1445 / 1445	100%	14.56	183 / 183
liver	100%	944.98	226 / 226	100%	14.43	406 / 406
ovary	100%	1101.12	180 / 180	100%	19.37	430 / 430
skin	100%	1500.33	1809 / 1809	100%	36.41	472 / 472
stomach	100%	1047.35	359 / 359	100%	19.08	286 / 286
thymus	100%	1086.75	653 / 653	100%	16.61	605 / 605
uterus	100%	1352.55	170 / 170	100%	18.48	458 / 459
brain	100%	1347.69	2636 / 2642	100%	14.95	705 / 705
pancreas	100%	798.16	327 / 328	100%	12.84	178 / 178
kidney	100%	1261.96	89 / 89	100%	11.04	898 / 901
intestine	100%	1374.34	966 / 966	100%	20.07	525 / 527
prostate	100%	1345.53	245 / 245	100%	14.52	500 / 502
breast	100%	1207.33	459 / 459	99%	18.01	1112 / 1118
adrenal gland	100%	1618.69	257 / 258	100%	13.98	229 / 230
lung	99%	1021.98	573 / 578	100%	14.81	1154 / 1155
adipose	100%	1077.58	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	24.86	80 / 80
lymph node	0%	0	0 / 0	100%	25.28	29 / 29
muscle	100%	2200.89	803 / 803	0%	0	0 / 0
spleen	100%	1333.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	16.27	45 / 45
ureter	0%	0	0 / 0	100%	16.89	1 / 1
blood vessel	100%	1111.87	1331 / 1335	0%	0	0 / 0
heart	98%	1223.37	847 / 861	0%	0	0 / 0
peripheral blood	96%	1040.44	895 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0070131	Biological process	positive regulation of mitochondrial translation
GO_0001522	Biological process	pseudouridine synthesis
GO_0006397	Biological process	mRNA processing
GO_0035770	Cellular component	ribonucleoprotein granule
GO_0005739	Cellular component	mitochondrion
GO_0005759	Cellular component	mitochondrial matrix
GO_0009982	Molecular function	pseudouridine synthase activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	RPUSD3
Protein name	Mitochondrial mRNA pseudouridine synthase RPUSD3 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 3) RNA pseudouridine synthase D3
Synonyms
Description	FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post-transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA . As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis . .
Accessions	ENST00000418713.6 H7C0K7 ENST00000423108.5 H7C454 Q6P087 H7C0R9 ENST00000433535.7 [Q6P087-6] ENST00000433972.2 ENST00000427174.5 C9JM75 ENST00000383820.10 [Q6P087-5] H7C1H7 ENST00000424438.5 ENST00000433555.1 H7C2C3 ENST00000433972.2 [Q6P087-4]

RPUSD3 report