RNF144A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0085020Biological processprotein K6-linked ubiquitination
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0000209Biological processprotein polyubiquitination
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000151Cellular componentubiquitin ligase complex
GO_0010008Cellular componentendosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameRNF144A
Protein nameRBR-type E3 ubiquitin transferase (EC 2.3.2.31)
Ring finger protein 144A
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
SynonymsRNF144
UBCE7IP4
KIAA0161
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage . Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways . Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination . Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol . .

AccessionsP50876
C9JLH4
ENST00000433456.1
ENST00000432850.1
ENST00000416587.5
ENST00000320892.11
H7C3G0