Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 15 studies | 51% ± 17% | |
endothelial cell | 14 studies | 30% ± 13% | |
oligodendrocyte precursor cell | 13 studies | 50% ± 18% | |
glutamatergic neuron | 12 studies | 51% ± 27% | |
astrocyte | 10 studies | 32% ± 13% | |
GABAergic neuron | 8 studies | 44% ± 21% | |
interneuron | 6 studies | 43% ± 13% | |
adipocyte | 5 studies | 21% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 33% ± 12% | |
neuron | 4 studies | 44% ± 16% | |
granule cell | 4 studies | 49% ± 8% | |
retinal cone cell | 4 studies | 45% ± 23% | |
fibroblast | 4 studies | 22% ± 6% | |
GABAergic interneuron | 3 studies | 30% ± 9% | |
epithelial cell | 3 studies | 30% ± 16% | |
pericyte | 3 studies | 29% ± 18% | |
retinal rod cell | 3 studies | 48% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 6078.06 | 2642 / 2642 | 99% | 34.70 | 701 / 705 |
prostate | 99% | 2757.31 | 243 / 245 | 100% | 27.68 | 501 / 502 |
adrenal gland | 100% | 6418.55 | 258 / 258 | 98% | 21.09 | 225 / 230 |
ovary | 100% | 3289.16 | 180 / 180 | 96% | 17.31 | 412 / 430 |
pancreas | 100% | 4657.70 | 328 / 328 | 95% | 19.85 | 169 / 178 |
breast | 100% | 2954.35 | 458 / 459 | 93% | 17.54 | 1042 / 1118 |
skin | 91% | 1104.95 | 1643 / 1809 | 100% | 49.23 | 470 / 472 |
uterus | 100% | 5995.68 | 170 / 170 | 88% | 19.86 | 403 / 459 |
lung | 94% | 1278.68 | 542 / 578 | 93% | 13.71 | 1074 / 1155 |
thymus | 90% | 1010.98 | 590 / 653 | 92% | 14.12 | 555 / 605 |
esophagus | 92% | 953.45 | 1330 / 1445 | 90% | 13.22 | 164 / 183 |
kidney | 98% | 1615.33 | 87 / 89 | 82% | 10.27 | 740 / 901 |
bladder | 95% | 974.81 | 20 / 21 | 84% | 10.98 | 421 / 504 |
intestine | 98% | 1433.34 | 945 / 966 | 76% | 8.54 | 402 / 527 |
stomach | 49% | 425.07 | 177 / 359 | 79% | 9.69 | 227 / 286 |
spleen | 100% | 4281.26 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2595.86 | 1201 / 1204 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 12.76 | 44 / 45 |
heart | 97% | 1268.25 | 832 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 14.77 | 75 / 80 |
muscle | 81% | 806.46 | 648 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 46% | 420.37 | 612 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 41% | 605.33 | 385 / 929 | 0% | 0 | 0 / 0 |
liver | 1% | 6.54 | 2 / 226 | 28% | 2.70 | 114 / 406 |
lymph node | 0% | 0 | 0 / 0 | 17% | 1.05 | 5 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0085020 | Biological process | protein K6-linked ubiquitination |
GO_0002221 | Biological process | pattern recognition receptor signaling pathway |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0000151 | Cellular component | ubiquitin ligase complex |
GO_0010008 | Cellular component | endosome membrane |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
Gene name | RNF144A |
Protein name | RBR-type E3 ubiquitin transferase (EC 2.3.2.31) Ring finger protein 144A E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4) |
Synonyms | RNF144 UBCE7IP4 KIAA0161 |
Description | FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage . Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways . Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination . Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol . . |
Accessions | P50876 C9JLH4 ENST00000433456.1 ENST00000432850.1 ENST00000416587.5 ENST00000320892.11 H7C3G0 |