RNASE6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0051607Biological processdefense response to virus
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0019731Biological processantibacterial humoral response
GO_0045087Biological processinnate immune response
GO_0006952Biological processdefense response
GO_0006401Biological processRNA catabolic process
GO_0005615Cellular componentextracellular space
GO_0005764Cellular componentlysosome
GO_0005576Cellular componentextracellular region
GO_0031410Cellular componentcytoplasmic vesicle
GO_0004540Molecular functionRNA nuclease activity
GO_0004519Molecular functionendonuclease activity
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameRNASE6
Protein nameRibonuclease K6 (RNase K6) (EC 3.1.27.-)
Ribonuclease K6
SynonymsRAD1
hCG_1640892
RNS6
DescriptionFUNCTION: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine . Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli . Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria . Probably contributes to urinary tract sterility . Bactericidal activity is independent of RNase activity . .

AccessionsQ6IB39
ENST00000304677.3
Q93091