RIMS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	13 studies	49% ± 17%	Explore
glutamatergic neuron	12 studies	78% ± 17%	Explore
GABAergic neuron	11 studies	65% ± 25%	Explore
astrocyte	9 studies	35% ± 18%	Explore
interneuron	6 studies	70% ± 22%	Explore
neuron	5 studies	48% ± 15%	Explore
respiratory goblet cell	5 studies	37% ± 13%	Explore
endothelial cell	4 studies	47% ± 22%	Explore
granule cell	4 studies	81% ± 10%	Explore
microglial cell	4 studies	38% ± 17%	Explore
retina horizontal cell	4 studies	42% ± 17%	Explore
oligodendrocyte	4 studies	34% ± 20%	Explore
GABAergic interneuron	3 studies	81% ± 3%	Explore
pericyte	3 studies	38% ± 16%	Explore
Mueller cell	3 studies	25% ± 4%	Explore
retinal bipolar neuron	3 studies	38% ± 11%	Explore
GABAergic amacrine cell	3 studies	51% ± 14%	Explore
OFF-bipolar cell	3 studies	57% ± 21%	Explore
ON-bipolar cell	3 studies	54% ± 22%	Explore
glycinergic amacrine cell	3 studies	37% ± 11%	Explore
amacrine cell	3 studies	60% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	48% ± 24%	Explore
eye	4 studies	22% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	6171.14	2538 / 2642	70%	4.17	494 / 705
prostate	9%	39.65	21 / 245	77%	2.36	387 / 502
adrenal gland	4%	32.22	10 / 258	58%	2.69	133 / 230
esophagus	43%	788.72	618 / 1445	8%	0.19	14 / 183
stomach	25%	235.72	89 / 359	9%	0.24	27 / 286
breast	1%	2.11	3 / 459	22%	0.91	243 / 1118
blood vessel	21%	99.93	282 / 1335	0%	0	0 / 0
lung	1%	4.84	6 / 578	10%	0.35	111 / 1155
pancreas	1%	2.94	3 / 328	3%	0.14	6 / 178
intestine	3%	16.10	30 / 966	1%	0.02	6 / 527
kidney	0%	0	0 / 89	4%	0.20	34 / 901
lymph node	0%	0	0 / 0	3%	0.34	1 / 29
uterus	1%	1.85	1 / 170	3%	0.11	12 / 459
adipose	3%	14.13	38 / 1204	0%	0	0 / 0
skin	2%	9.28	32 / 1809	1%	0.03	5 / 472
bladder	0%	0	0 / 21	2%	0.04	11 / 504
ovary	2%	5.36	3 / 180	0%	0.02	2 / 430
eye	0%	0	0 / 0	1%	0.03	1 / 80
liver	0%	0	0 / 226	0%	0.01	2 / 406
muscle	0%	1.48	3 / 803	0%	0	0 / 0
thymus	0%	2.11	1 / 653	0%	0.02	1 / 605
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007601	Biological process	visual perception
GO_0048791	Biological process	calcium ion-regulated exocytosis of neurotransmitter
GO_0042391	Biological process	regulation of membrane potential
GO_0017156	Biological process	calcium-ion regulated exocytosis
GO_0061025	Biological process	membrane fusion
GO_0010628	Biological process	positive regulation of gene expression
GO_0006886	Biological process	intracellular protein transport
GO_1903861	Biological process	positive regulation of dendrite extension
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0046928	Biological process	regulation of neurotransmitter secretion
GO_2000463	Biological process	positive regulation of excitatory postsynaptic potential
GO_0065003	Biological process	protein-containing complex assembly
GO_0060478	Biological process	acrosomal vesicle exocytosis
GO_0045055	Biological process	regulated exocytosis
GO_0046903	Biological process	secretion
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0030154	Biological process	cell differentiation
GO_0097151	Biological process	positive regulation of inhibitory postsynaptic potential
GO_0050806	Biological process	positive regulation of synaptic transmission
GO_2000300	Biological process	regulation of synaptic vesicle exocytosis
GO_0005886	Cellular component	plasma membrane
GO_0042734	Cellular component	presynaptic membrane
GO_0048786	Cellular component	presynaptic active zone
GO_0048788	Cellular component	cytoskeleton of presynaptic active zone
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0031267	Molecular function	small GTPase binding
GO_0030695	Molecular function	GTPase regulator activity
GO_0046872	Molecular function	metal ion binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RIMS1
Protein name	Regulating synaptic membrane exocytosis 1 RIMS1 protein Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2) Alternative protein RIMS1
Synonyms	KIAA0340 RAB3IP2 RIM1 Nbla00761
Description	FUNCTION: Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes . .
Accessions	ENST00000518273.5 [Q86UR5-6] ENST00000520567.5 [Q86UR5-7] ENST00000425662.6 [Q86UR5-10] ENST00000517433.5 ENST00000401910.7 [Q86UR5-12] ENST00000517960.5 [Q86UR5-5] ENST00000523963.5 [Q86UR5-13] E5RGM0 Q3ZCW0 ENST00000517827.5 [Q86UR5-9] L8ECF5 ENST00000522291.5 [Q86UR5-8] Q86UR5 ENST00000264839.11 [Q86UR5-4] ENST00000697193.1 ENST00000522211.5 A0A8V8TKU9 ENST00000521978.6 [Q86UR5-1] A0A0C4DFV1 ENST00000370420.8 ENST00000453976.6 H0YBU6 ENST00000414192.2 [Q86UR5-11] H0YBE7 ENST00000491071.6 [Q86UR5-3]

RIMS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review