I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 16 studies | 42% ± 18% | |
| fibroblast | 7 studies | 20% ± 3% | |
| smooth muscle cell | 4 studies | 26% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 16 studies | 42% ± 18% | |
| fibroblast | 7 studies | 20% ± 3% | |
| smooth muscle cell | 4 studies | 26% ± 10% |
Insufficient scRNA-seq data for expression of RGMA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 5394.60 | 2513 / 2642 | 100% | 94.68 | 703 / 705 |
| ovary | 99% | 5363.09 | 179 / 180 | 82% | 8.66 | 352 / 430 |
| uterus | 100% | 8026.99 | 170 / 170 | 62% | 8.00 | 285 / 459 |
| esophagus | 100% | 13574.16 | 1445 / 1445 | 62% | 11.36 | 113 / 183 |
| breast | 100% | 4674.20 | 457 / 459 | 39% | 4.12 | 434 / 1118 |
| stomach | 83% | 9931.53 | 299 / 359 | 37% | 6.22 | 107 / 286 |
| intestine | 90% | 8364.28 | 871 / 966 | 20% | 1.84 | 107 / 527 |
| prostate | 77% | 1774.13 | 188 / 245 | 29% | 1.23 | 144 / 502 |
| muscle | 100% | 16485.81 | 803 / 803 | 0% | 0 | 0 / 0 |
| adipose | 99% | 3721.89 | 1186 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 96% | 2937.49 | 1278 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 15.77 | 41 / 45 |
| skin | 62% | 1610.20 | 1128 / 1809 | 20% | 1.68 | 96 / 472 |
| thymus | 69% | 1306.90 | 448 / 653 | 14% | 1.74 | 83 / 605 |
| bladder | 62% | 1185.76 | 13 / 21 | 18% | 1.44 | 92 / 504 |
| heart | 79% | 1727.53 | 676 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 76% | 3.99 | 61 / 80 |
| lung | 14% | 262.95 | 83 / 578 | 53% | 9.42 | 611 / 1155 |
| pancreas | 24% | 359.07 | 78 / 328 | 35% | 4.25 | 63 / 178 |
| adrenal gland | 4% | 58.47 | 10 / 258 | 4% | 0.48 | 10 / 230 |
| kidney | 4% | 63.28 | 4 / 89 | 1% | 0.23 | 11 / 901 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.07 | 4 / 406 |
| peripheral blood | 1% | 14.74 | 8 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030510 | Biological process | regulation of BMP signaling pathway |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0048681 | Biological process | negative regulation of axon regeneration |
| GO_0051044 | Biological process | positive regulation of membrane protein ectodomain proteolysis |
| GO_0048671 | Biological process | negative regulation of collateral sprouting |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0001843 | Biological process | neural tube closure |
| GO_0006509 | Biological process | membrane protein ectodomain proteolysis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0031175 | Biological process | neuron projection development |
| GO_0009986 | Cellular component | cell surface |
| GO_0098552 | Cellular component | side of membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_1990459 | Molecular function | transferrin receptor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RGMA |
| Protein name | RGMA protein Repulsive guidance molecule A (RGM domain family member A) Repulsive guidance molecule BMP co-receptor a Repulsive guidance molecule A |
| Synonyms | RGM |
| Description | FUNCTION: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. . |
| Accessions | G3V4C2 ENST00000554387.5 ENST00000542321.6 [Q96B86-3] A1L187 ENST00000329082.12 [Q96B86-1] ENST00000557301.2 [Q96B86-4] A0A0G2JL92 ENST00000556658.1 ENST00000543599.5 [Q96B86-3] G3V3Z3 A0A0A0MTQ4 F5H7G2 Q96B86 ENST00000557420.1 ENST00000555598.1 C6G485 ENST00000425933.6 [Q96B86-3] ENST00000557301 G3V545 ENST00000556950.1 |
