RFX6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RFX6 at tissue level.

III. Associated gene sets

GO_0003309Biological processtype B pancreatic cell differentiation
GO_0050796Biological processregulation of insulin secretion
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0003311Biological processpancreatic D cell differentiation
GO_0003310Biological processpancreatic A cell differentiation
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0090104Biological processpancreatic epsilon cell differentiation
GO_0031018Biological processendocrine pancreas development
GO_0042593Biological processglucose homeostasis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRFX6
Protein nameDNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)
SynonymsRFXDC1
DescriptionFUNCTION: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin . Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes . Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription . .

AccessionsENST00000332958.3
Q8HWS3