RECQL5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RECQL5 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_1990414Biological processreplication-born double-strand break repair via sister chromatid exchange
GO_0000278Biological processmitotic cell cycle
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0051301Biological processcell division
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0072757Biological processcellular response to camptothecin
GO_0006260Biological processDNA replication
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0006259Biological processDNA metabolic process
GO_0051304Biological processchromosome separation
GO_1990506Biological processmitotic DNA-templated DNA replication
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0097550Cellular componenttranscription preinitiation complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0009378Molecular functionfour-way junction helicase activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0003678Molecular functionDNA helicase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016853Molecular functionisomerase activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0043138Molecular function3'-5' DNA helicase activity

IV. Literature review

[source]
Gene nameRECQL5
Protein nameRecQ like helicase 5
ATP-dependent DNA helicase Q5 (EC 5.6.2.4) (DNA 3'-5' helicase RecQ5) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)
RECQL5 protein
ATP-dependent DNA helicase (EC 3.6.4.12)
RECQL5 protein (RecQ protein-like 5, isoform CRA_b)
SynonymsRECQ5
hCG_1989322
DescriptionFUNCTION: DNA helicase that plays an important role in DNA replication, transcription and repair . Probably unwinds DNA in a 3'-5' direction (Probable). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability . Associates also with POLR1A and enforces the stability of ribosomal DNA arrays . Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress . Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis . Required for efficient DNA repair, including repair of inter-strand cross-links . Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. A core helicase fragment (residues 11-609) binds preferentially to splayed duplex, looped and ssDNA . .

AccessionsJ3KRM6
ENST00000578201.5
J3KSV9
ENST00000423245.6 [O94762-4]
ENST00000340830.9 [O94762-3]
ENST00000582464.5
A5YM55
ENST00000580078.1
J3KSL7
ENST00000584999.1 [O94762-3]
O94762
ENST00000420326.6 [O94762-2]
J3QLU0
ENST00000582548.1
ENST00000580707.1
J3KTQ2
Q6FIC9
ENST00000317905.10 [O94762-1]
ENST00000581825.1
Q9BW80
J3KS37