Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 7 studies | 57% ± 17% | |
| retinal rod cell | 6 studies | 31% ± 8% | |
| retinal bipolar neuron | 5 studies | 28% ± 7% | |
| mast cell | 3 studies | 17% ± 2% | |
| OFF-bipolar cell | 3 studies | 22% ± 3% | |
| ON-bipolar cell | 3 studies | 26% ± 1% | |
| rod bipolar cell | 3 studies | 41% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 5 studies | 26% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 29% | 27.31 | 76 / 258 | 57% | 9.82 | 132 / 230 |
| bladder | 86% | 132.48 | 18 / 21 | 1% | 0.02 | 4 / 504 |
| stomach | 83% | 71.06 | 299 / 359 | 1% | 0.02 | 3 / 286 |
| uterus | 76% | 68.75 | 130 / 170 | 5% | 0.14 | 21 / 459 |
| prostate | 76% | 72.57 | 187 / 245 | 0% | 0.05 | 1 / 502 |
| esophagus | 72% | 78.98 | 1043 / 1445 | 0% | 0 | 0 / 183 |
| intestine | 67% | 56.17 | 648 / 966 | 0% | 0.00 | 1 / 527 |
| lung | 66% | 53.88 | 383 / 578 | 0% | 0.01 | 5 / 1155 |
| adipose | 48% | 22.30 | 574 / 1204 | 0% | 0 | 0 / 0 |
| breast | 41% | 19.63 | 187 / 459 | 1% | 0.03 | 13 / 1118 |
| pancreas | 38% | 9.09 | 126 / 328 | 3% | 0.06 | 6 / 178 |
| blood vessel | 28% | 8.37 | 375 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 8% | 2.28 | 15 / 180 | 18% | 0.58 | 78 / 430 |
| heart | 25% | 5.41 | 215 / 861 | 0% | 0 | 0 / 0 |
| skin | 24% | 10.66 | 438 / 1809 | 0% | 0.00 | 1 / 472 |
| brain | 17% | 12.46 | 456 / 2642 | 4% | 0.46 | 30 / 705 |
| kidney | 15% | 6.91 | 13 / 89 | 1% | 0.01 | 8 / 901 |
| muscle | 11% | 1.90 | 85 / 803 | 0% | 0 | 0 / 0 |
| thymus | 8% | 1.69 | 54 / 653 | 1% | 0.03 | 9 / 605 |
| eye | 0% | 0 | 0 / 0 | 9% | 2.64 | 7 / 80 |
| spleen | 2% | 0.40 | 5 / 241 | 0% | 0 | 0 / 0 |
| liver | 2% | 0.26 | 4 / 226 | 0% | 0 | 0 / 406 |
| peripheral blood | 0% | 0.02 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0015031 | Biological process | protein transport |
| GO_0060041 | Biological process | retina development in camera-type eye |
| GO_0031283 | Biological process | negative regulation of guanylate cyclase activity |
| GO_0001917 | Cellular component | photoreceptor inner segment |
| GO_0005768 | Cellular component | endosome |
| GO_0120199 | Cellular component | cone photoreceptor outer segment |
| GO_0120200 | Cellular component | rod photoreceptor outer segment |
| GO_0001750 | Cellular component | photoreceptor outer segment |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| Gene name | RD3 |
| Protein name | Protein RD3 (Retinal degeneration protein 3) Alternative protein RD3 |
| Synonyms | C1orf36 |
| Description | FUNCTION: Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors . Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors . Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment . Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP . Plays an important role for the survival of rods and cones in the retina (By similarity). . |
| Accessions | ENST00000367002.5 L8EAU4 ENST00000680073.1 Q7Z3Z2 |
