RBM7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051321Biological processmeiotic cell cycle
GO_0016076Biological processsnRNA catabolic process
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0017069Molecular functionsnRNA binding
GO_0071889Molecular function14-3-3 protein binding
GO_0005515Molecular functionprotein binding
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRBM7
Protein nameRNA-binding protein 7 (RNA-binding motif protein 7)
RNA binding motif protein 7
SynonymshCG_2032547
DescriptionFUNCTION: RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation . NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs . Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) . Participates in several biological processes including DNA damage response (DDR) and stress response . During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome . Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability . .

AccessionsF5H674
J3KPD3
ENST00000375490.10
ENST00000544313.5
G3V1T9
ENST00000540163.5
F5GXV8
Q9Y580
ENST00000542140.5
F5GY08
F5H606
Q6IRX3
ENST00000544582.1
ENST00000545678.1
ENST00000541475.5