RAD54L report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RAD54L at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAD54L at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0045003Biological processdouble-strand break repair via synthesis-dependent strand annealing
GO_0010212Biological processresponse to ionizing radiation
GO_0008340Biological processdetermination of adult lifespan
GO_0007131Biological processreciprocal meiotic recombination
GO_0006338Biological processchromatin remodeling
GO_0051321Biological processmeiotic cell cycle
GO_0051276Biological processchromosome organization
GO_0006310Biological processDNA recombination
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0004386Molecular functionhelicase activity
GO_0015616Molecular functionDNA translocase activity
GO_0036310Molecular functionATP-dependent DNA/DNA annealing activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRAD54L
Protein nameRAD54 like
Alternative protein RAD54L
DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)
SynonymsRAD54A
DescriptionFUNCTION: Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks . Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). .

AccessionsL8E913
A0A590UJ90
ENST00000669994.1
A0A087WV39
V9GYD3
ENST00000442598.5
ENST00000476687.2
Q92698
A0A590UJJ7
A0A087WW72
ENST00000473251.2
ENST00000655446.1
A0A087X124
ENST00000661701.1
ENST00000469835.6
ENST00000459678.2
V9GYX6
ENST00000472889.2
ENST00000493032.5
ENST00000657122.1
A0A590UJ71
A0A590UJQ8
A0A087WWG5
ENST00000671528.1
A0A087WTB0
ENST00000493985.5
ENST00000488942.5
ENST00000463715.5
ENST00000371975.9
A0A087WVW5