RAD51C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	27% ± 8%	Explore
oligodendrocyte	4 studies	16% ± 1%	Explore
hematopoietic precursor cell	3 studies	17% ± 1%	Explore
ciliated cell	3 studies	19% ± 1%	Explore
erythroblast	3 studies	30% ± 12%	Explore
GABAergic neuron	3 studies	26% ± 4%	Explore
glutamatergic neuron	3 studies	38% ± 8%	Explore
dendritic cell	3 studies	24% ± 3%	Explore
natural killer cell	3 studies	20% ± 5%	Explore
CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	26% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	863.16	245 / 245	100%	11.95	502 / 502
brain	100%	884.84	2638 / 2642	100%	11.41	705 / 705
uterus	100%	718.86	170 / 170	100%	12.59	458 / 459
bladder	100%	678.81	21 / 21	99%	9.08	501 / 504
thymus	100%	490.10	652 / 653	99%	6.95	601 / 605
breast	100%	689.42	459 / 459	99%	12.63	1104 / 1118
esophagus	100%	632.19	1442 / 1445	99%	6.48	181 / 183
lung	99%	506.83	571 / 578	100%	8.46	1151 / 1155
skin	100%	575.77	1802 / 1809	99%	11.59	466 / 472
stomach	100%	555.24	359 / 359	98%	6.07	281 / 286
ovary	100%	689.74	180 / 180	98%	6.68	420 / 430
pancreas	98%	280.19	323 / 328	98%	5.70	175 / 178
intestine	100%	652.44	962 / 966	97%	6.15	511 / 527
adrenal gland	100%	833.98	258 / 258	96%	7.42	221 / 230
kidney	100%	533.04	89 / 89	95%	5.89	853 / 901
liver	96%	263.04	217 / 226	96%	5.35	390 / 406
blood vessel	100%	830.75	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	14.84	29 / 29
spleen	100%	735.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	12.07	45 / 45
ureter	0%	0	0 / 0	100%	4.81	1 / 1
adipose	100%	644.17	1203 / 1204	0%	0	0 / 0
muscle	100%	463.36	799 / 803	0%	0	0 / 0
heart	98%	770.80	843 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	6.76	76 / 80
peripheral blood	55%	478.34	507 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007062	Biological process	sister chromatid cohesion
GO_0006281	Biological process	DNA repair
GO_0007283	Biological process	spermatogenesis
GO_0010971	Biological process	positive regulation of G2/M transition of mitotic cell cycle
GO_0007066	Biological process	female meiosis sister chromatid cohesion
GO_0007131	Biological process	reciprocal meiotic recombination
GO_0000722	Biological process	telomere maintenance via recombination
GO_0007141	Biological process	male meiosis I
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0000707	Biological process	meiotic DNA recombinase assembly
GO_0006310	Biological process	DNA recombination
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0005657	Cellular component	replication fork
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0033063	Cellular component	Rad51B-Rad51C-Rad51D-XRCC2 complex
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0030054	Cellular component	cell junction
GO_0033065	Cellular component	Rad51C-XRCC3 complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0008821	Molecular function	crossover junction DNA endonuclease activity
GO_0140664	Molecular function	ATP-dependent DNA damage sensor activity
GO_0000400	Molecular function	four-way junction DNA binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RAD51C
Protein name	DNA repair protein RAD51 homolog 3 DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) RAD51 paralog C RAD51 homolog C (S. cerevisiae) (RAD51 paralog C) (RAD51C protein) (cDNA FLJ76539, highly similar to Homo sapiens RAD51 homolog C (S. cerevisiae) (RAD51C), transcript variant 3, mRNA)
Synonyms	RAD51L2 hCG_2000975
Description	FUNCTION: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD51 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. .
Accessions	ENST00000461271.6 J3QKK3 ENST00000697686.1 ENST00000697681.1 ENST00000486827.1 A0A8V8TML8 ENST00000413590.5 ENST00000584617.5 ENST00000583539.5 A0A087WZ35 O43502 ENST00000697685.1 J3QLQ2 ENST00000697680.1 ENST00000697694.1 A0A8V8TMU8 J3QLB5 ENST00000475762.5 ENST00000697689.1 ENST00000584804.1 ENST00000697690.1 ENST00000487525.5 ENST00000697692.1 E9PI66 A0A8V8TML3 ENST00000697683.1 ENST00000421782.3 [O43502-2] H7C1R0 ENST00000482007.5 A0A8V8TL64 Q7KZJ0 J3QR58 ENST00000337432.9 [O43502-1] ENST00000622327.4 ENST00000697691.1 H7C2Q5 ENST00000425173.5

RAD51C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review