I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 4 studies | 29% ± 8% | |
| mast cell | 3 studies | 18% ± 2% | |
| melanocyte | 3 studies | 36% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 4 studies | 29% ± 8% | |
| mast cell | 3 studies | 18% ± 2% | |
| melanocyte | 3 studies | 36% ± 14% |
Insufficient scRNA-seq data for expression of RAB38 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 83% | 1843.16 | 1494 / 1809 | 94% | 244.63 | 442 / 472 |
| thymus | 71% | 198.37 | 464 / 653 | 91% | 27.26 | 552 / 605 |
| lung | 77% | 246.97 | 447 / 578 | 80% | 50.08 | 927 / 1155 |
| kidney | 60% | 163.09 | 53 / 89 | 84% | 20.34 | 754 / 901 |
| adrenal gland | 100% | 1468.28 | 258 / 258 | 36% | 39.67 | 82 / 230 |
| uterus | 58% | 216.56 | 98 / 170 | 76% | 52.95 | 347 / 459 |
| bladder | 57% | 268.52 | 12 / 21 | 59% | 37.30 | 297 / 504 |
| esophagus | 41% | 1021.25 | 591 / 1445 | 73% | 60.11 | 133 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 677.66 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 35.68 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 66.19 | 40 / 45 |
| breast | 27% | 72.98 | 126 / 459 | 61% | 23.57 | 678 / 1118 |
| ovary | 13% | 32.14 | 24 / 180 | 50% | 12.53 | 213 / 430 |
| pancreas | 1% | 2.73 | 4 / 328 | 48% | 11.90 | 85 / 178 |
| prostate | 34% | 102.93 | 84 / 245 | 3% | 0.37 | 15 / 502 |
| intestine | 16% | 40.70 | 158 / 966 | 16% | 3.41 | 86 / 527 |
| adipose | 20% | 60.39 | 245 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 182.35 | 182 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 18% | 55.13 | 242 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 2.04 | 4 / 29 |
| spleen | 14% | 36.59 | 33 / 241 | 0% | 0 | 0 / 0 |
| stomach | 4% | 9.79 | 14 / 359 | 8% | 1.38 | 24 / 286 |
| liver | 0% | 0.91 | 1 / 226 | 8% | 1.64 | 31 / 406 |
| heart | 2% | 5.64 | 21 / 861 | 0% | 0 | 0 / 0 |
| brain | 0% | 0.50 | 4 / 2642 | 2% | 0.28 | 11 / 705 |
| muscle | 0% | 0.57 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035646 | Biological process | endosome to melanosome transport |
| GO_1904377 | Biological process | positive regulation of protein localization to cell periphery |
| GO_0090383 | Biological process | phagosome acidification |
| GO_2001247 | Biological process | positive regulation of phosphatidylcholine biosynthetic process |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0032438 | Biological process | melanosome organization |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0007005 | Biological process | mitochondrion organization |
| GO_0060155 | Biological process | platelet dense granule organization |
| GO_0007264 | Biological process | small GTPase-mediated signal transduction |
| GO_0048023 | Biological process | positive regulation of melanin biosynthetic process |
| GO_0015031 | Biological process | protein transport |
| GO_0072657 | Biological process | protein localization to membrane |
| GO_1903232 | Biological process | melanosome assembly |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0016020 | Cellular component | membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005769 | Cellular component | early endosome |
| GO_0005764 | Cellular component | lysosome |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0033162 | Cellular component | melanosome membrane |
| GO_0044233 | Cellular component | mitochondria-associated endoplasmic reticulum membrane contact site |
| GO_0005829 | Cellular component | cytosol |
| GO_0045335 | Cellular component | phagocytic vesicle |
| GO_0031905 | Cellular component | early endosome lumen |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0044297 | Cellular component | cell body |
| GO_0042470 | Cellular component | melanosome |
| GO_0035612 | Molecular function | AP-2 adaptor complex binding |
| GO_0030742 | Molecular function | GTP-dependent protein binding |
| GO_0035651 | Molecular function | AP-3 adaptor complex binding |
| GO_0005525 | Molecular function | GTP binding |
| GO_0036461 | Molecular function | BLOC-2 complex binding |
| GO_0035650 | Molecular function | AP-1 adaptor complex binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | RAB38 |
| Protein name | RAB38, member RAS oncogene family Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1) Ras-related protein Rab |
| Synonyms | |
| Description | FUNCTION: May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis . Plays an important role in the control of melanin production and melanosome biogenesis . In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). . FUNCTION: The small GTPases Rab are key regulators in vesicle trafficking. . |
| Accessions | ENST00000531138.1 P57729 ENST00000526372.1 ENST00000243662.11 H0YDB7 H0YEA4 |
