Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 6 studies | 24% ± 4% | |
| enterocyte | 5 studies | 22% ± 4% | |
| epithelial cell of proximal tubule | 4 studies | 20% ± 2% | |
| epithelial cell | 4 studies | 30% ± 10% | |
| hepatocyte | 4 studies | 28% ± 8% |
Insufficient scRNA-seq data for expression of RAB17 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 6709.61 | 226 / 226 | 97% | 46.01 | 394 / 406 |
| kidney | 100% | 4921.38 | 89 / 89 | 97% | 39.29 | 872 / 901 |
| pancreas | 100% | 1791.42 | 328 / 328 | 96% | 23.79 | 170 / 178 |
| thymus | 100% | 3275.15 | 653 / 653 | 90% | 23.98 | 545 / 605 |
| prostate | 86% | 770.83 | 210 / 245 | 100% | 30.12 | 500 / 502 |
| lung | 98% | 1548.42 | 566 / 578 | 73% | 14.30 | 842 / 1155 |
| stomach | 80% | 2406.70 | 286 / 359 | 90% | 15.22 | 258 / 286 |
| breast | 59% | 723.68 | 270 / 459 | 90% | 22.67 | 1008 / 1118 |
| intestine | 50% | 1003.70 | 484 / 966 | 95% | 17.94 | 500 / 527 |
| skin | 28% | 89.20 | 509 / 1809 | 90% | 44.60 | 424 / 472 |
| bladder | 38% | 174.05 | 8 / 21 | 75% | 11.24 | 380 / 504 |
| ovary | 21% | 59.27 | 37 / 180 | 85% | 11.40 | 364 / 430 |
| eye | 0% | 0 | 0 / 0 | 100% | 61.55 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.39 | 1 / 1 |
| esophagus | 39% | 159.72 | 570 / 1445 | 49% | 7.56 | 89 / 183 |
| uterus | 25% | 107.16 | 43 / 170 | 49% | 8.64 | 227 / 459 |
| adrenal gland | 19% | 79.51 | 48 / 258 | 7% | 2.23 | 16 / 230 |
| blood vessel | 23% | 65.93 | 313 / 1335 | 0% | 0 | 0 / 0 |
| heart | 20% | 65.15 | 176 / 861 | 0% | 0 | 0 / 0 |
| adipose | 17% | 60.12 | 203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 5% | 13.74 | 41 / 803 | 0% | 0 | 0 / 0 |
| brain | 2% | 7.01 | 65 / 2642 | 0% | 0.05 | 3 / 705 |
| spleen | 2% | 12.22 | 6 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.18 | 1 / 45 |
| peripheral blood | 1% | 11.64 | 13 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0060271 | Biological process | cilium assembly |
| GO_0051489 | Biological process | regulation of filopodium assembly |
| GO_0006897 | Biological process | endocytosis |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0002415 | Biological process | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor |
| GO_0032456 | Biological process | endocytic recycling |
| GO_0050773 | Biological process | regulation of dendrite development |
| GO_0032401 | Biological process | establishment of melanosome localization |
| GO_0032402 | Biological process | melanosome transport |
| GO_0051963 | Biological process | regulation of synapse assembly |
| GO_0030100 | Biological process | regulation of endocytosis |
| GO_0046847 | Biological process | filopodium assembly |
| GO_0045056 | Biological process | transcytosis |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030139 | Cellular component | endocytic vesicle |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0098794 | Cellular component | postsynapse |
| GO_0030425 | Cellular component | dendrite |
| GO_0042470 | Cellular component | melanosome |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0019003 | Molecular function | GDP binding |
| GO_0005525 | Molecular function | GTP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | RAB17 |
| Protein name | RAB17, member RAS oncogene family Ras-related protein Rab-17 RAB17 protein |
| Synonyms | |
| Description | FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration. . |
| Accessions | H7C1P7 ENST00000409822.1 [Q9H0T7-2] ENST00000430445.1 ENST00000411462.5 B8ZZM5 ENST00000264601.8 [Q9H0T7-1] C9J0T6 Q6FIH2 ENST00000392001.6 Q9H0T7 F8WBE9 F8WAG1 ENST00000414278.1 ENST00000409576.1 |
