QTRT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0101030Biological processtRNA-guanine transglycosylation
GO_0006400Biological processtRNA modification
GO_0005741Cellular componentmitochondrial outer membrane
GO_0032991Cellular componentprotein-containing complex
GO_1990234Cellular componenttransferase complex
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0046872Molecular functionmetal ion binding
GO_0008479Molecular functiontRNA-guanosine(34) queuine transglycosylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameQTRT1
Protein nameQueuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)
Queuine tRNA-ribosyltransferase catalytic subunit 1
FP3235 (Queuine tRNA-ribosyltransferase 1 (TRNA-guanine transglycosylase), isoform CRA_b)
SynonymsTGT
TGUT
hCG_2033722
DescriptionFUNCTION: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) . Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Modification of cytoplasmic tRNAs with queuosine controls the elongation speed of cognate codons, thereby ensuring the correct folding of nascent proteins to maintain proteome integrity . .

FUNCTION: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product. .

AccessionsENST00000592376.1
ENST00000250237.10 [Q9BXR0-1]
K7EJ21
ENST00000587599.5
Q71RF8
ENST00000592254.1
K7EL95
ENST00000591643.1
K7ESP6
K7EPI1
Q9BXR0
ENST00000421333.6 [Q9BXR0-2]
B2RAR3