Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 8 studies | 30% ± 13% | |
goblet cell | 7 studies | 29% ± 11% | |
endothelial cell | 7 studies | 23% ± 7% | |
glutamatergic neuron | 6 studies | 31% ± 18% | |
fibroblast | 6 studies | 23% ± 5% | |
astrocyte | 6 studies | 27% ± 8% | |
intestinal crypt stem cell | 5 studies | 41% ± 18% | |
transit amplifying cell | 5 studies | 32% ± 10% | |
GABAergic neuron | 5 studies | 28% ± 14% | |
plasma cell | 4 studies | 23% ± 6% | |
retina horizontal cell | 4 studies | 24% ± 9% | |
oligodendrocyte precursor cell | 4 studies | 19% ± 3% | |
basal cell | 4 studies | 27% ± 10% | |
hematopoietic precursor cell | 3 studies | 24% ± 9% | |
myofibroblast cell | 3 studies | 19% ± 3% | |
pericyte | 3 studies | 20% ± 5% | |
enterocyte | 3 studies | 22% ± 7% | |
ciliated cell | 3 studies | 24% ± 3% | |
abnormal cell | 3 studies | 22% ± 1% | |
dendritic cell | 3 studies | 23% ± 1% | |
enteroendocrine cell | 3 studies | 26% ± 7% | |
interneuron | 3 studies | 26% ± 12% | |
neuron | 3 studies | 26% ± 7% | |
adipocyte | 3 studies | 29% ± 7% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2721.11 | 1445 / 1445 | 100% | 24.14 | 183 / 183 |
liver | 100% | 2549.16 | 226 / 226 | 100% | 34.17 | 406 / 406 |
pancreas | 100% | 4884.52 | 328 / 328 | 100% | 33.72 | 178 / 178 |
thymus | 100% | 5822.49 | 653 / 653 | 100% | 44.91 | 605 / 605 |
uterus | 100% | 3838.45 | 170 / 170 | 100% | 48.81 | 459 / 459 |
brain | 100% | 3622.95 | 2637 / 2642 | 100% | 58.84 | 705 / 705 |
ovary | 100% | 4595.12 | 180 / 180 | 100% | 40.60 | 429 / 430 |
adrenal gland | 100% | 3934.85 | 258 / 258 | 100% | 41.80 | 229 / 230 |
prostate | 100% | 4609.25 | 245 / 245 | 99% | 53.23 | 499 / 502 |
kidney | 100% | 4044.54 | 89 / 89 | 99% | 38.63 | 895 / 901 |
intestine | 100% | 3228.14 | 966 / 966 | 99% | 53.77 | 523 / 527 |
skin | 100% | 2791.44 | 1809 / 1809 | 99% | 45.61 | 468 / 472 |
stomach | 100% | 2397.31 | 359 / 359 | 99% | 45.55 | 283 / 286 |
bladder | 100% | 3156.67 | 21 / 21 | 99% | 49.29 | 498 / 504 |
lung | 99% | 2125.45 | 575 / 578 | 98% | 28.60 | 1137 / 1155 |
breast | 100% | 3367.98 | 459 / 459 | 98% | 32.36 | 1092 / 1118 |
adipose | 100% | 2645.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 48.67 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 64.13 | 29 / 29 |
spleen | 100% | 3135.87 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 42.76 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 49.46 | 1 / 1 |
blood vessel | 100% | 2141.72 | 1330 / 1335 | 0% | 0 | 0 / 0 |
muscle | 98% | 1559.31 | 789 / 803 | 0% | 0 | 0 / 0 |
heart | 97% | 1534.82 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 44% | 703.58 | 406 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0101030 | Biological process | tRNA-guanine transglycosylation |
GO_0006400 | Biological process | tRNA modification |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_1990234 | Cellular component | transferase complex |
GO_0005634 | Cellular component | nucleus |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0008479 | Molecular function | tRNA-guanosine(34) queuine transglycosylase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | QTRT1 |
Protein name | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) Queuine tRNA-ribosyltransferase catalytic subunit 1 FP3235 (Queuine tRNA-ribosyltransferase 1 (TRNA-guanine transglycosylase), isoform CRA_b) |
Synonyms | TGT TGUT hCG_2033722 |
Description | FUNCTION: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) . Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). Modification of cytoplasmic tRNAs with queuosine controls the elongation speed of cognate codons, thereby ensuring the correct folding of nascent proteins to maintain proteome integrity . . FUNCTION: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product. . |
Accessions | ENST00000592376.1 ENST00000250237.10 [Q9BXR0-1] K7EJ21 ENST00000587599.5 Q71RF8 ENST00000592254.1 K7EL95 ENST00000591643.1 K7ESP6 K7EPI1 Q9BXR0 ENST00000421333.6 [Q9BXR0-2] B2RAR3 |