PYM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_1903259Biological processexon-exon junction complex disassembly
GO_0045727Biological processpositive regulation of translation
GO_0005730Cellular componentnucleolus
GO_0030054Cellular componentcell junction
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043022Molecular functionribosome binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePYM1
Protein nameWIBG protein
PYM homolog 1, exon junction complex associated factor
Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)
SynonymsPYM
WIBG
DescriptionFUNCTION: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. .

AccessionsENST00000408946.7 [Q9BRP8-1]
ENST00000454792.2
Q9BRP8
H0YJW5
Q96DC3
ENST00000398213.4 [Q9BRP8-2]
ENST00000549939.1
F8VT68