PWWP2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001178Biological processregulation of transcriptional start site selection at RNA polymerase II promoter
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0120325Molecular functionNuRD complex binding
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene namePWWP2A
Protein namePWWP domain containing 2A
PWWP domain-containing protein 2A
SynonymsMST101
KIAA1935
DescriptionFUNCTION: Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes . Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z . Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression . .

AccessionsENST00000523662.1 [Q96N64-3]
ENST00000307063.9 [Q96N64-1]
ENST00000521424.1
H0YC06
H0YB44
ENST00000456329.7 [Q96N64-2]
ENST00000524050.5
Q96N64