PTPN14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001946Biological processlymphangiogenesis
GO_0006470Biological processprotein dephosphorylation
GO_0046825Biological processregulation of protein export from nucleus
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene namePTPN14
Protein nameProtein tyrosine phosphatase non-receptor type 14 (EC 3.1.3.48)
PTPN14 protein
Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
SynonymsPEZ
PTPD2
DescriptionFUNCTION: Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. .

AccessionsENST00000366956.10
ENST00000543945.5
Q15678
E2J9M0
Q6PJC3