PTGES2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTGES2 at tissue level.

III. Associated gene sets

GO_0046903Biological processsecretion
GO_0019371Biological processcyclooxygenase pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006629Biological processlipid metabolic process
GO_0035578Cellular componentazurophil granule lumen
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0043295Molecular functionglutathione binding
GO_0003677Molecular functionDNA binding
GO_0050220Molecular functionprostaglandin-E synthase activity
GO_0016829Molecular functionlyase activity
GO_0020037Molecular functionheme binding
GO_0005515Molecular functionprotein binding
GO_0036134Molecular function12-hydroxyheptadecatrienoic acid synthase activity

IV. Literature review

[source]
Gene namePTGES2
Protein nameProstaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2)
Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]
Prostaglandin E synthase 2
SynonymsPGES2
hCG_1785478
C9orf15
DescriptionFUNCTION: Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) . The biological function and the GSH-dependent property of PTGES2 is still under debate . In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity). .

AccessionsA0A7I2V460
A0A7I2V4L3
ENST00000678174.1
Q9H7Z7
ENST00000338961.11
ENST00000676562.1
ENST00000449878.1
ENST00000677651.1
A0A7I2V5T7
ENST00000617202.4
A0A7I2V5X6
ENST00000277462.9
X6RJ95
ENST00000677980.1
ENST00000474124.6
ENST00000679345.1
ENST00000677691.1
ENST00000678916.1
A0A7I2V308
A6NHH0
A0A7I2YQ70