PPM1E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0006470Biological processprotein dephosphorylation
GO_0005730Cellular componentnucleolus
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePPM1E
Protein nameProtein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA)
SynonymsKIAA1072
POPX1
CAMKN
DescriptionFUNCTION: Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). .

AccessionsENST00000308249.4 [Q8WY54-2]
Q8WY54